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  1. No Access

    Article

    Glutamic acid – amino acid, neurotransmitter, and drug – is responsible for protein synthesis rhythm in hepatocyte populations in vitro and in vivo

    Primary cultures of rat hepatocytes were studied in serum-free media. Ultradian protein synthesis rhythm was used as a marker of cell synchronization in the population. Addition of glutamic acid (0.2 mg/ml) to...

    V. Y. Brodsky, L. A. Malchenko, D. S. Konchenko, N. D. Zvezdina… in Biochemistry (Moscow) (2016)

  2. No Access

    Article

    Dopamine disorganizes direct intercellular interactions in keratinocytes cultures: A comparison to hepatocytes

    Dopamine in the concentration 0.4 μg/mL abolishes protein synthesis rhythm in HaCaT keratinocytes and hepatocytes unlike noradrenaline or melatonin, which synchronize direct intercellular interactions and orga...

    V. Ya. Brodskii, E. A. Vorotelyak… in Russian Journal of Developmental Biology (2016)

  3. No Access

    Article

    Blockade of proteasome activity disturbs the rhythm of synthesis of the protein marker of direct cell-cell interactions

    The effect of inhibition of proteasome activity on direct cell-cell interactions in primary hepatocyte cultures was studied. The circahoralian rhythm of protein synthesis was a marker of cell-cell communicatio...

    V. Ya. Brodskii, N. P. Sharova… in Russian Journal of Developmental Biology (2015)

  4. No Access

    Article

    Administration of Dopamine to Rats Disorganizes the Rhythm of Protein Synthesis in Hepatocytes

    Dopamine was injected intravenously (9 μg/kg) or intraperitoneally (15 μg/kg) to Wistar rats (3-4 months, 300-400 g). Hepatocytes were isolated 40 min after dopamine injection. Dense cultures were maintained o...

    V. Ya. Brodskii, L. A. Mal’chenko… in Bulletin of Experimental Biology and Medic… (2014)

  5. No Access

    Article

    Effect of Protein Synthesis Rhythm-Organizing Signal Persists for a Day after Single Administration of Melatonin to Rat

    Melatonin administered to rat intraperitoneally organizes ultradian rhythm of protein synthesis in hepatocytes that persists for 1 day after exposure to the synchronizing signal. Hepatocytes were isolated 1 da...

    N. D. Zvezdina, L. A. Malchenko… in Bulletin of Experimental Biology and Medic… (2014)

  6. No Access

    Article

    Dopamine Disorganizes the Rhythm of Protein Synthesis Disrupting Self-Organization of Hepatocytes In Vitro

    We studied dense 24-hour cultures of rat hepatocytes in serum-free medium on collagencoated slides. As before, a circahoralian rhythm of protein synthesis was observed in control cultures in a fresh medium. No...

    V. Y. Brodskii, T. K. Dubovaya… in Bulletin of Experimental Biology and Medic… (2013)