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Open AccessNon-targeted urine metabolomics and associations with prevalent and incident type 2 diabetes
Better risk prediction and new molecular targets are key priorities in type 2 diabetes (T2D) research. Little is known about the role of the urine metabolome in predicting the risk of T2D. We aimed to use non-...
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Open AccessGlucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance
Insulin resistance (IR) predisposes to type 2 diabetes and cardiovascular disease but its causes are incompletely understood. Metabolic challenges like the oral glucose tolerance test (OGTT) can reveal pathoge...
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Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes
Identification of novel biomarkers for type 2 diabetes and their genetic determinants could lead to improved understanding of causal pathways and improve risk prediction.
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New genetic loci link adipose and insulin biology to body fat distribution
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distr...
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Genetic studies of body mass index yield new insights for obesity biology
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), ...
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Defining the role of common variation in the genomic and biological architecture of adult human height
Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci signif...
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Open AccessLow serum adiponectin concentrations are associated with insulin sensitivity independent of obesity in Sudanese subjects with type 2 diabetes mellitus
Prevalence of Type 2 diabetes mellitus among Sudanese population was found to be 3.4% and associated with high rates of complications and obesity. Different adipocytokines are secreted from adipose tissues, am...
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Open AccessEfficacy of screening for high blood pressure in dental health care
There is consensus on the importance of early detection and treatment of high blood pressure. Dental care is one of few medical services to which a considerable proportion of the general population comes for r...
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The economic and quality of life impact of hypoglycemia
Hypoglycemia is an often underrecognized side effect of type 2 diabetes therapy. This study assessed the burden of hypoglycemia in this population in Sweden and included 309 patients aged 35 years or older and...
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Open AccessComparison of rosuvastatin and atorvastatin for lipid lowering in patients with type 2 diabetes mellitus: results from the URANUS study
The Use of Rosuvastatin versus Atorvastatin iN type 2 diabetes mellitUS (URANUS) study compared rosuvastatin with atorvastatin for the reduction of low-density lipoprotein cholesterol (LDL-C) in patients with ...
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Acute elevations of medium-and long-chain fatty acids have different impacts on endothelium-dependent vasodilation in humans
It has previously been shown that acute elevation of long-chain fatty acids (LCFA) impairs endothelium-dependent vasodilation (EDV) in humans. In this study, we tested the hypothesis that an elevation of both ...
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Improved hemorheological properties during infusion of a lipid emulsion (Intralipid) in healthy subjects
Objectives: Lipid emulsions are commonly used for nutrition in critically ill patients. In these patients interventions resulting in deteriorated blood rheology and thereby an impaired microcirc...
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35th Annual Meeting of the European Association for the Study of Diabetes
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Improving prognosis in NIDDM patients
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The kidney in Type 2 (non-insulin-dependent) diabetes mellitus
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Cancer risk in patients with diabetes mellitus
Cancer incidence was ascertained in a population-based cohort of 51,008 patients in Uppsala, Sweden, who were given a discharge diagnosis of diabetes mellitus during 1965–83. Complete follow-up through 1984 wi...
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Effects of Diet Fat P/S Ratio on Serum Lipoprotein Concentrations
In several countries diet programs have been carried out with the goal to decrease the serum cholesterol concentration and in the long perspective decrease morbidity and mortality of ischemic heart disease of ...
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Lung Maturation in Fetuses of Diabetic Rats
Summary: Pulmonary maturation in diabetic pregnancy has been studied in the 20-day-old fetuses of manifest diabetic rats. The animals were either untreated or treated with insulin. The diabetic state was induc...
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Eighth annual meeting of the European Association for the Study of Diabetes
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Annual Meeting of the Scandinavian Society for the Study of Diabetes