Microstructural Parcellation of the Human Cerebral Cortex
From Brodmann's Post-Mortem Map to in Vivo Map** with High-Field Magnetic Resonance Imaging
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Open AccessEarly-stage multi-cancer detection using an extracellular vesicle protein-based blood test
Detecting cancer at early stages significantly increases patient survival rates. Because lethal solid tumors often produce few symptoms before progressing to advanced, metastatic disease, diagnosis frequently ...
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Article
Open AccessThe World Checklist of Vascular Plants, a continuously updated resource for exploring global plant diversity
The World Checklist of Vascular Plants (WCVP) is a comprehensive list of scientifically described plant species, compiled over four decades, from peer-reviewed literature, authoritative scientific databases, h...
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Article
Identifying gaps in the photographic record of the vascular plant flora of the Americas
Field photographs of plant species are crucial for research and conservation, but the lack of a centralized database makes them difficult to locate. We surveyed 25 online databases of field photographs and fou...
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Article
Cultural neuroscience and global mental health: addressing grand challenges
Mental, neurological and substance-use (MNS) disorders comprise approximately 13% of the global burden of disease. The Grand Challenges in Global Mental Health Initiative has recently identified research prior...
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Article
Peter Mansfield (1933–2017)
Physicist who developed MRI, revolutionizing medicine.
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Article
Habenula volume increases with disease severity in unmedicated major depressive disorder as revealed by 7T MRI
The habenula is a paired epithalamic structure involved in the pathogenesis of major depressive disorder (MDD). Evidence comes from its impact on the regulation of serotonergic and dopaminergic neurons, the ro...
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Article
In favor of general probability distributions: lateral prefrontal and insular cortices respond to stimulus inherent, but irrelevant differences
A key aspect of optimal behavior is the ability to predict what will come next. To achieve this, we must have a fairly good idea of the probability of occurrence of possible outcomes. This is based both on pri...
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Article
Open AccessSpatial normalization of ultrahigh resolution 7 T magnetic resonance imaging data of the postmortem human subthalamic nucleus: a multistage approach
In this paper, we describe a novel processing strategy for the spatial normalization of ultrahigh resolution magnetic resonance imaging (MRI) data of small ex vivo samples into MNI standard space. We present a...
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Article
Transparent thin shield for radio frequency transmit coils
To identify a shielding material compatible with optical head-motion tracking for prospective motion correction and which minimizes radio frequency (RF) radiation losses at 7 T without sacrificing line-of-sigh...
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Article
Open AccessMulti-modal ultra-high resolution structural 7-Tesla MRI data repository
Structural brain data is key for the understanding of brain function and networks, i.e., connectomics. Here we present data sets available from the ‘atlasing of the basal ganglia (ATAG)’ project, which provide...
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Article
Open AccessThe functional architecture of S1 during touch observation described with 7 T fMRI
Recent studies indicate that the primary somatosensory cortex (S1) is active not only when touch is physically perceived but also when it is merely observed to be experienced by another person. This social res...
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Diffusion imaging-based subdivision of the human hypothalamus: a magnetic resonance study with clinical implications
The hypothalamus and its subdivisions are involved in many neuropsychiatric conditions such as affective disorders, schizophrenia, or narcolepsy, but parcellations of hypothalamic subnuclei have hitherto been ...
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Book
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Chapter and Conference Paper
Multi-modal Surface-Based Alignment of Cortical Areas Using Intra-cortical T1 Contrast
The position of cortical areas in the brain is related to cortical folding patterns; however, intersubject variability remains, particularly for higher cortical areas. Current cortical surface registration tec...
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Chapter and Conference Paper
Quantifying Differences Between Primary Cortical Areas in Humans Based on Laminar Profiles in In-Vivo MRI Data
This paper presents an approach for map** the human cortical architecture in vivo based on quantitative MRI indices of myelin. We automatically construct laminar profiles in several primary cortical areas an...
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Chapter and Conference Paper
A Histology-Based Model of Quantitative T1 Contrast for In-vivo Cortical Parcellation of High-Resolution 7 Tesla Brain MR Images
A conclusive map** of myeloarchitecture (myelin patterns) onto the cortical sheet and, thus, a corresponding map** to cytoarchitecture (cell configuration) does not exist today. In this paper we present a ...
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Chapter
Where Matters: New Approaches to Brain Analysis
Emerging MRI and fMRI methods, most effective at high magnetic field, provide details of brain cortical architecture and function that are very difficult to include in analysis methods established in the 1990s...
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Chapter
MRI Methods for In-Vivo Cortical Parcellation
The advent of whole-body MRI scanners at field strengths as high as 7 T has enabled a dramatic improvement of the spatial resolution of human brain images, in all three major attributes: structure, function an...
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Article
An embedded optical tracking system for motion-corrected magnetic resonance imaging at 7T
Prospective motion correction using data from optical tracking systems has been previously shown to reduce motion artifacts in MR imaging of the head. We evaluate a novel optical embedded tracking system.
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Article
Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group
The metalloprotease activity of lethal factor (LF) from Bacillus anthracis (B. anthracis) is a main source of toxicity in the lethality of anthrax infection. Thus, the understanding of the enzymatic activity and ...
