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Open AccessAssociations between epigenetic aging and diabetes mellitus in a Swedish longitudinal study
Diabetes mellitus type 2 (T2D) is associated with accelerated biological aging and the increased risk of onset of other age-related diseases. Epigenetic changes in DNA methylation levels have been found to ser...
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Article
Open AccessMajor cardiovascular events and death in parents of children with type 1 diabetes: a register-based matched cohort study in Sweden
Parenting a child with type 1 diabetes has been associated with stress-related symptoms. This study aimed to elucidate the potential impact on parental risk of major cardiovascular events (MCE) and death.
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Article
Open AccessAnalysis of plasma metabolomes from 11 309 subjects in five population-based cohorts
Plasma metabolomics holds potential for precision medicine, but limited information is available to compare the performance of such methods across multiple cohorts. We compared plasma metabolite profiles after...
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Article
Open AccessMarkers of imminent myocardial infarction
Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent first myocardial infarction and design relevant prediction mod...
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Article
Open AccessEvidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women
The percentage of people without children over their lifetime is approximately 25% in men and 20% in women. Individual diseases have been linked to childlessness, mostly in women, yet we lack a comprehensive p...
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Article
Open AccessPulmonary function and atherosclerosis in the general population: causal associations and clinical implications
Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, em...
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Article
Open AccessPrevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals—a Swedish population-based study
Patients with type 2 diabetes have an increased risk of death and cardiovascular events and people with diabetes or prediabetes have been found to have increased atherosclerotic burden in the coronary and caro...
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Article
Open AccessThe metabolomic profiling of total fat and fat distribution in a multi-cohort study of women and men
Currently studies aiming for the comprehensive metabolomics profiling of measured total fat (%) as well as fat distribution in both sexes are lacking. In this work, bioimpedance analysis was applied to measure...
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Article
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin ac...
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Open AccessAuthor Correction: An online atlas of human plasma metabolite signatures of gut microbiome composition
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Open AccessIdentification of three bacterial species associated with increased appendicular lean mass: the HUNT study
Appendicular lean mass (ALM) associates with mobility and bone mineral density (BMD). While associations between gut microbiota composition and ALM have been reported, previous studies rely on relatively small...
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Article
Targeted proteomics identifies potential biomarkers of dysglycaemia, beta cell function and insulin sensitivity in Black African men and women
Using a targeted proteomics approach, we aimed to identify and validate circulating proteins associated with impaired glucose metabolism (IGM) and type 2 diabetes in a Black South African cohort. In addition, ...
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Article
Open AccessAn online atlas of human plasma metabolite signatures of gut microbiome composition
Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circul...
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Article
Open AccessSpatio-temporal predictions of COVID-19 test positivity in Uppsala County, Sweden: a comparative approach
Previous spatio-temporal COVID-19 prediction models have focused on the prediction of subsequent number of cases, and have shown varying accuracy and lack of high geographical resolution. We aimed to predict t...
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The COVID-19 pandemic may be receding but the diabetes pandemic rages on
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Open AccessDevelopment of gut microbiota during the first 2 years of life
Although development of microbiota in childhood has been linked to chronic immune-related conditions, early childhood determinants of microbiota development have not been fully elucidated. We used 16S rRNA seq...
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Open AccessApp-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden
The app-based COVID Symptom Study was launched in Sweden in April 2020 to contribute to real-time COVID-19 surveillance. We enrolled 143,531 study participants (≥18 years) who contributed 10.6 million daily sy...
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Open AccessAuthor Correction: Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts
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Article
Open AccessThe ABCC4 gene is associated with pyometra in golden retriever dogs
Pyometra is one of the most common diseases in female dogs, presenting as purulent inflammation and bacterial infection of the uterus. On average 20% of intact female dogs are affected before 10 years of age, ...
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Author Correction: Attributes and predictors of long COVID
