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Article
Open AccessBlocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood–brain barrier
Disruption of blood–brain barrier (BBB) integrity is a feature of various neurological disorders. Here we found that the BBB is differently affected during the preclinical, progression and remission phase of e...
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Article
Open AccessVEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake
Type 2 diabetes mellitus (T2DM) affects millions of people and is linked with obesity and lipid accumulation in peripheral tissues. Increased lipid handling and lipotoxicity in insulin producing β-cells may co...
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Article
Open AccessNoninvasive intravital high-resolution imaging of pancreatic neuroendocrine tumours
Preclinical trials of cancer drugs in animal models are important for drug development. The Rip1Tag2 (RT2) transgenic mouse, a model of pancreatic neuroendocrine tumours (PNET), has provided immense knowledge ...
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Article
Open AccessThe Smart City Active Mobile Phone Intervention (SCAMPI) study to promote physical activity through active transportation in healthy adults: a study protocol for a randomised controlled trial
The global pandemic of physical inactivity represents a considerable public health challenge. Active transportation (i.e., walking or cycling for transport) can contribute to greater total physical activity le...
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Article
Open AccessTranscriptomic analysis of the harvested endothelial cells in a swine model of mechanical thrombectomy
In mechanical thrombectomy (MT) for ischemic stroke, endothelial cells (ECs) from intracranial blood vessels adhere to the stent retriever device and can be harvested. However, understanding the molecular biol...
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Article
Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling
Paracrine signaling networks in the breast cancer microenvironment uncover determinants of hormone receptor status and offer opportunities for therapeutic intervention.
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Article
Impact of a five-dimensional framework on R&D productivity at AstraZeneca
In 2011, AstraZeneca set out to improve its research and development (R&D) productivity by focusing decision-making using a framework with five technical determinants: the right target, right tissue, right saf...
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Article
Open AccessMicroglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke
Treatment of acute ischemic stroke with the thrombolytic tissue plasminogen activator (tPA) can significantly improve neurological outcomes; however, thrombolytic therapy is associated with an increased risk o...
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Article
Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney
Metabolic diseases, such as obesity and diabetes, are a serious burden for the health system. Vascular endothelial growth factor (VEGF)-B has been shown to regulate tissue uptake and accumulation of fatty acid...
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Article
Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unknown origins. Neurodegeneration in ALS mouse models occurs together with signs of disrupted blood–spinal cord barrier (BSCB) and...
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Article
Longitudinal Assessment of Physical Activity in Women Undergoing Roux-en-Y Gastric Bypass
Patients undergoing bariatric surgery do not seem to increase objectively measured physical activity (PA) after surgery, despite substantial weight loss. The aims of the present study were (i) to objectively c...
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Article
Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease
Excess lipid accumulation in peripheral tissues is a key feature of many metabolic diseases. Therefore, techniques for imaging and quantifying lipids in various tissues are important for understanding and eval...
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Article
Open AccessWalkability parameters, active transportation and objective physical activity: moderating and mediating effects of motor vehicle ownership in a cross-sectional study
Neighborhood walkability has been associated with physical activity in several studies. However, as environmental correlates of physical activity may be context specific, walkability parameters need to be inve...
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Article
Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes
Inhibition of VEGF-B signalling is shown to limit ectopic fatty-acid accumulation, restore peripheral insulin sensitivity and muscle glucose uptake, and preserve pancreatic islet functionality.
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Article
Open AccessAvailability of exercise facilities and physical activity in 2,037 adults: cross-sectional results from the Swedish neighborhood and physical activity (SNAP) study
Exercise facilities may have the potential to promote physical activity among residents, and to support an active lifestyle throughout the year. We investigated the association between objectively assessed ava...
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Article
Vascular endothelial growth factor B controls endothelial fatty acid uptake
VEGF-B, a vascular endothelial growth factor that is highly expressed in heart, skeletal muscle and brown adipose tissue, has been found to have an unexpected role in targeting lipids to peripheral tissues. VE...
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Article
Open AccessRisk of obesity in immigrants compared with Swedes in two deprived neighbourhoods
Despite a strong social gradient in the prevalence of obesity, there is little scientific understanding of obesity in people settled in deprived neighbourhoods. Few studies are actually based on objectively me...
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Article
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
tPA is a clot-buster used to treat stroke, but if it's given too late after stroke onset, it can cause complications like hemorrhage. Daniel Lawrence and his colleagues show that a US Food and Drug Administrat...
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Article
A new oral anticoagulant: the 50-year challenge
During the twentieth century, it was gradually recognized that thrombosis is a major cause of morbidity and mortality in the Western world. There is therefore ...
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Article
PDGF-D is a potent transforming and angiogenic growth factor
Platelet-derived growth factors (PDGFs) are important for normal tissue growth and maintenance. Overexpression of the classical PDGFs, PDGF-A and PDGF-B, has been linked to several diseases, including cancer, ...
