82 Result(s)
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Biomedicine
Biomedicine, general
Pharmacology/Toxicology
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Article
Metabolism of methyltertiary-butyl ether by rat hepatic microsomes
Exposure to methyltertiary-butyl ether (MTBE), a commonly used octane booster in gasoline, has previously been shown to alter various muscle, kidney, and liver metabolic activities. In the present study, the meta...
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Article
Alteration of rat liver microsomal monooxygenase activities by gasoline treatment
Previous work has shown an increase in rat liver enzyme activities after chronic exposure to gasoline vapor. In the present study, male Sprague-Dawley rats were pretreated with unleaded gasoline at 1 and 5 ml/...
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Article
Role of cytochromes P450 in the metabolism of methyl tert -butyl ether in human livers
Methyl tert-butyl ether (MTBE) is widely used as a gasoline oxygenate for more complete combustion in order to reduce the air pollution caused by motor vehicle exhaust. The possible adverse effects of MTBE on hu...
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Article
Effect of 4-tert-octylphenol on cytochrome P450 enzymes in rat liver
The effects were studied of 4-tert-octylphenol (OP) on hepatic cytochrome P450 enzymes in rats. Rats were treated intraperitoneally with OP twice, at doses of 5, 10, and 20 mg/kg. Among the cytochrome P450-depen...
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Article
Embryo lethality and teratogenicity of a new fluoroquinolone antibacterial DW-116 in rats
DW-116, 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-l-piperazinyl)-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride, is a newly developed fluoroquinolone antibacterial. The potential of DW-116 to i...
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Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells
The effect of the phospholipase A2 inhibitor palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling in Madin Darby canine kidney (MDCK) cells was examined using fura-2 as the fluorescent Ca2+ indicator. At...
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Tamoxifen-induced Ca2+ mobilization in bladder female transitional carcinoma cells
This study examined the effect of tamoxifen, an anti-breast cancer drug, on Ca2+ handling in bladder female transitional cancer cells. Changes in cytosolic free Ca2+ levels were recorded by using the Ca2+-sensit...
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Effect of the neuroprotective agent riluzole on intracellular Ca2+ levels in IMR32 neuroblastoma cells
Riluzole is an effective neuroprotective drug. Its effect on intracellular free Ca2+ levels ([Ca2+]i) has not been explored. This study examined the effect of riluzole on [Ca2+]i in IMR32 neuroblastoma cells usi...
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Article
Novel action of lignans isolated from Hernandia nymphaeifolia on Ca2+ signaling in human neutrophils
The effects of five lignans (epi-aschantin, epi-magnolin, epi-yangambin, deoxypodophyllotoxin, yatein) isolated from Hernandia nymphaeifolia (Presl.) Kubitzki (Hernandiaceae) on intracellular Ca2+ levels ([Ca2+]
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Article
The anti-breast cancer drug tamoxifen alters Ca2+ movement in Chinese hamster ovary (CHO-K1) cells
The anti-breast cancer drug tamoxifen has recently been shown to cause an increase in intracellular free-Ca2+ concentrations ([Ca2+]i) in renal tubular cells, breast cells and bladder cells. Because tamoxifen is ...
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Article
Sulfhydryl modification by 4,4′-dithiodipyridine induces calcium mobilization in human osteoblast-like cells
The effect of oxidants on Ca2+ movement in osteoblasts is unclear. In this study, we show that 4,4′-dithiodipyridine (4,4′-DTDP), a reactive disulphide that mobilizes Ca2+ in muscle, induces an increase in cytopl...
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Article
Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes
The elucidation of the HIV life cycle from the mid-1980s onwards revealed targets for therapeutic intervention, ultimately leading to the development of severa...
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Article
Effect of the antidepressant maprotiline on calcium movement and the viability of renal tubular cells
In Madin-Darby canine kidney (MDCK) cells, the effect of maprotiline, an antidepressant, on intracellular Ca2+ concentration ([Ca2+]i) was measured using fura-2. Maprotiline (>2.5 µM) caused a rapid rise of [Ca2+
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Article
Multiple actions of lysophosphatidylcholine in human Jurkat T cells
To obtain pathophysiological meanings of lysophosphatidylcholine (LPC) through the investigation of the effects of LPC in Jurkat T cells.
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Article
Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal Keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release
Jet fuels are complex mixtures of aliphatic (ALI) and aromatic (ARO) hydrocarbons that vary significantly in individual cytotoxicity and proinflammatory activity in human epidermal keratinocytes (HEK). In orde...
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Article
Cytotoxic and apoptotic effects of prenylflavonoid artonin B in human acute lymphoblastic leukemia cells
To investigate the anticancer effects and molecular mechanism of artonin B on the human acute lymphoblastic leukemia CCRF-CEM cells compared with other prenylflavonoid compounds.
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Article
Stimulation of melanogenesis by scoparone in B16 melanoma cells
The effect of coumarin derivatives on melanogenesis was investigated in B16 murine melanoma cells.
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Article
Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata
To investigate the effect of water soluble-ethanol precipitation fraction (AC-1) and alkaline extraction-isoelectric precipitation fraction (AC-2) from Antrodia camphorata (Polyporaceae, Aphyllophorales) on lipop...
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Article
Open AccessNucleotide receptor signalling and the generation of reactive oxygen species
Elevated levels of extracellular nucleotides are present at sites of inflammation, platelet degranulation and cellular damage or lysis. These extracellular nucleotides can lead to the activation of purinergic ...
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Protective effects of magnolol against oxidized LDL-induced apoptosis in endothelial cells
Magnolol, a compound extracted from the Chinese medicinal herb Magnolia officinalis, has several biological effects. However, its protective effects against endothelial injury remain unclear. In this study, we ex...
