23 Result(s)
within
Nancy A. Monteiro-Riviere
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Article
Open AccessDevelopment of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats
Physiologically based pharmacokinetic (PBPK) modeling is an important tool in predicting target organ dosimetry and risk assessment of nanoparticles (NPs). The methodology of building a multi-route PBPK model ...
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Reference Work Entry In depth
In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles
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Living Reference Work Entry In depth
In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles
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Article
In Vitro Biocompatibility and Antibacterial Efficacy of a Degradable Poly(l-lactide-co-epsilon-caprolactone) Copolymer Incorporated with Silver Nanoparticles
Silver nanoparticles (Ag-nps) are currently used as a natural biocide to prevent undesired bacterial growth in clothing, cosmetics and medical products. The objective of the study was to impart antibacterial p...
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Article
Growth of Zircone on Nanoporous Alumina Using Molecular Layer Deposition
Molecular layer deposition (MLD) is a sequential and self-limiting process that may be used to create hybrid organic/inorganic thin films from organometallic precursors and organic alcohol precursors. In this ...
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Article
Biocompatibility analysis of an electrically-activated silver-based antibacterial surface system for medical device applications
The costs associated with the treatment of medical device and surgical site infections are a major cause of concern in the global healthcare system. To prevent transmission of such infections, a prophylactic s...
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Article
Ultrananocrystalline Diamond-Coated Microporous Silicon Nitride Membranes for Medical Implant Applications
Ultrananocrystalline diamond (UNCD) exhibits excellent biological and mechanical properties, which make it an appropriate choice for promoting epidermal cell migration on the surfaces of percutaneous implants....
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Article
Deposition of antimicrobial coatings on microstereolithography-fabricated microneedles
Microneedles are small-scale needle-like projections that may be used for transdermal delivery of pharmacologic agents, including protein-containing and nucleic acid-containing agents. Commercial translation o...
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Article
An index for characterization of nanomaterials in biological systems
In a physiological environment, nanoparticles selectively absorb proteins to form ‘nanoparticle–protein coronas’1,2,3,4,5, a process governed by molecular interactions between chemical groups on the nanoparticle ...
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Article
Stretchable diamond-like carbon microstructures for biomedical applications
Designing, fabricating, and evaluating stretchable electronics is a growing area of materials research. Electronic devices have traditionally been fabricated using rigid, inorganic substrates (e.g., silicon) w...
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Article
Atomic layer deposition of TiO2 thin films on nanoporous alumina templates: Medical applications
Nanostructured materials may play a significant role in controlled release of pharmacologic agents for treatment of cancer. Many nanoporous polymer materials are inadequate for use in drug delivery. Nanoporous...
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Article
Characterization of microfluidic human epidermal keratinocyte culture
Human epidermal keratinocytes (HEK) are skin cells of primary importance in maintaining the body’s defensive barrier and are used in vitro to assess the irritation potential and toxicity of chemical compounds....
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Article
Towards an in vivo biologically inspired nanofactory
Nanotechnology is having a major impact on medicine and the treatment of disease, notably in imaging and targeted drug delivery. It may, however, be possible to go even further and design 'pseudo-cell' nanofac...
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Article
Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal Keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release
Jet fuels are complex mixtures of aliphatic (ALI) and aromatic (ARO) hydrocarbons that vary significantly in individual cytotoxicity and proinflammatory activity in human epidermal keratinocytes (HEK). In orde...
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Article
A Compartment Model for the Membrane-Coated Fiber Technique Used for Determining the Absorption Parameters of Chemicals into Lipophilic Membranes
Purpose. The purpose of this work was to develop a compartment model for the membrane-coated fiber (MCF) technique for determining the absorption parameters of chemicals into lipophilic membranes.
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Article
A Novel in-Vitro Technique for Studying Percutaneous Permeation with a Membrane-Coated Fiber and Gas Chromatography/Mass Spectrometry: Part I. Performances of the Technique and Determination of the Permeation Rates and Partition Coefficients of Chemical Mixtures
Purpose. To develop a novel in-vitro technique for rapid assessment of percutaneous absorption of chemical mixtures.
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Chapter
Transdermal Peptide Delivery Using Electroporation
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Article
Effect of Selective Lipid Extraction from Different Body Regions on Epidermal Barrier Function
Purpose. To assess the effects of selective lipid extraction and tape strip** on transepidermal water loss (TEWL) at three body regions in the pig.
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Article
Transdermal lontophoretic Delivery of Luteinizing Hormone Releasing Hormone (LHRH): Effect of Repeated Administration
The transdermal iontophoretic delivery of the reproductive peptide hormone, luteinizing hormone releasing hormone (LHRH) is investigated in the isolated perfused porcine skin flap model (IPPSF). LHRH is delive...
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Article
Identification of the Pathway of lontophoretic Drug Delivery: Light and Ultrastructural Studies Using Mercuric Chloride in Pigs
Although electrically assisted transdermal drug delivery has recently achieved a great deal of research attention, the precise anatomical pathway followed by these drugs through the stratum corneum has not bee...
