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  1. No Access

    Article

    Identification of heat shock protein 90α as an IMH-2 epitope-associated protein and correlation of its mRNA overexpression with colorectal cancer metastasis and poor prognosis

    We studied whether HSP90α was associated with the special carbohydrate structures IMH-2 epitopes, and investigated its mRNA expression and clinical relevance in colorectal cancer (CRC) patients.

    Wei-Shone Chen, Chun-Chung Lee… in International Journal of Colorectal Disease (2011)

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    Article

    Sesamin Inhibits Macrophage-Induced Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 Expression and Proangiogenic Activity in Breast Cancer Cells

    Sesamin is a sesame component with antihypertensive and antioxidative activities and has recently aroused much interest in studying its potential anticancer application. Macrophage is one of the infiltrating i...

    Chun-Chung Lee, Ko-Jiunn Liu, Yu-Chen Wu, Sue-Jane Lin, Ching-Chun Chang… in Inflammation (2011)

  3. Article

    Cytotoxic and apoptotic effects of prenylflavonoid artonin B in human acute lymphoblastic leukemia cells

    To investigate the anticancer effects and molecular mechanism of artonin B on the human acute lymphoblastic leukemia CCRF-CEM cells compared with other prenylflavonoid compounds.

    Chun-chung Lee, Chun-nan Lin, Guey-mei Jow in Acta Pharmacologica Sinica (2006)

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  4. Article

    Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells

    Hyperbaric oxygen (HBO) is increasingly used in a number of areas of medical practice, such as selected problem infections and wounds. The beneficial effects of HBO in treating ischemia-related wounds may be m...

    Chun-Chung Lee, Shu-Chen Chen, Shiow-Chwen Tsai… in Journal of Biomedical Science (2006)

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  5. No Access

    Article

    Sesamol induces nitric oxide release from human umbilical vein endothelial cells

    Sesamol, which is derived from sesame seed lignans, is reportedly an antioxidant. Nitric oxide (NO), the most important vascular relaxing factor, is regulated in the endothelium. In addition, NO is involved in...

    Pey-Rong Chen, Chingmin E. Tsai, Hang Chang, Tsuei-Ling Liu, Chun-Chung Lee in Lipids (2005)

  6. No Access

    Article

    A Novel Topoisomerase II Poison GL331 Preferentially Induces DNA Cleavage at (C/G)T Sites and Can Cause Telomere DNA Damage

    Purpose. Topoisomerase II (Topo II) preferentially cuts DNA at alternating purine-pyrimidine repeats. Different Topo II poisons may affect Topo II to produce distinct drug-specific DNA cleavage patterns. GL331 i...

    Chun-Chung Lee, Tze-Sing Huang in Pharmaceutical Research (2001)

  7. No Access

    Article

    In vitro evaluation of GL331's cancer cell killing and apoptosis-inducing activity in combination with other chemotherapeutic agents

    GL331 is a novel podophyllotoxin-derived compound and is more efficacious than its congener VP-16 in killing several types of cancer cells, that has promoted considerable interest in its possibility of clinica...

    Tze-Sing Huang, Chih-Hung Shu, Chun-Chung Lee, Li-Tzong Chen… in Apoptosis (2000)

  8. No Access

    Article

    A Novel Podophyllotoxin-Derived Compound GL331 Is More Potent than Its Congener VP-16 in Killing Refractory Cancer Cells

    Purpose. GL331 is a new homolog of VP-16, and has demonstrated more efficacious anti-cancer activity in both the in vitro and in vivo lymphoma systems. To extensively explore GL331's clinical value, we furthermo...

    Tze-Sing Huang, Chun-Chung Lee, Yee Chao, Chih-Hung Shu… in Pharmaceutical Research (1999)