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Article
Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite becomes a ligand
GPR35, an orphan receptor, has been waiting for its ligand since its cloning in 1998. Many endogenous and exogenous molecules have been suggested to act as agonists of GPR35 including kynurenic acid, zaprinast...
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Article
Inhibitory Effect of Oroxylin A in a Mouse Model of Atopic Dermatitis
Scutellaria baicalensis has long been used in Asian traditional medicine to prevent and treat suppurative dermatitis, allergic diseases, inflammation, hyperlipemia, and arteriosclerosis. Oroxylin A is a flavone p...
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Article
Blockage of sphingosine-1-phosphate receptor 2 attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice
Sphingosine-1-phosphate (S1P) and its receptors have been implicated in functions of Langerhans cells and atopic dermatitis. In this study, we investigated the roles of S1P receptor type 2 (S1P2) in a mouse model...
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Open AccessThe protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model
Extracellular acidification in the brain has been observed in ischemia; however, the physiological and pathophysiological implications of the pH reduction remain largely unknown. Here, we analyzed the roles of...
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Free fatty acid receptor 4 (FFA4) activation ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by increasing regulatory T cells in mice
High dose intake of docosahexaenoic acid showed beneficial effects on atopic dermatitis in patients and was found to increase regulatory T cells in mice, but its molecular target has not been identified. Free ...
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Free Fatty Acid Receptor 4 Mediates the Beneficial Effects of n-3 Fatty Acids on Body Composition in Mice
As populations continue to age worldwide, sarcopenic obesity has heightened interest due to its medical importance. Although much evidence now indicates that n-3 fatty acids (FAs) may have beneficial effects o...
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Open AccessOmega-3 fatty acids induce Ca2+ mobilization responses in human colon epithelial cell lines endogenously expressing FFA4
Free fatty acid receptor 4 (FFA4; formerly known as GPR120) is the G protein-coupled receptor (GPCR) for omega-3 polyunsaturated fatty acids. FFA4 has been found to express in the small intestines and colons o...
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Article
Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance
Recent studies on senescence marker protein-30 (SMP30) have shown that it has an important functional role in the aging process, but its precise participation in cellular works has not been fully determined. W...
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Open AccessAge-related inflammation and insulin resistance: a review of their intricate interdependency
Chronic inflammation is a major risk factor underlying aging and the associated diseases of aging; of particular interest is insulin resistance during aging. Chronic inflammation impairs normal lipid accumulat...
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Article
The essential role of FoxO6 phosphorylation in aging and calorie restriction
Changes in the activities of FoxOs caused by phosphorylation, acetylation, or ubiquitination induce expressional changes in the genes involved in the modulation of oxidative stress by modifying histones and ch...
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Article
Open AccessYin and Yang of ginseng pharmacology: ginsenosides vs gintonin
Ginseng, the root of Panax ginseng, has been used in traditional Chinese medicine as a tonic herb that provides many beneficial effects. Pharmacologic studies in the last decades have shown that ginsenosides (gin...
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Article
How to die chemically? whole body apoptosis
What would you do if your body decided to die when you were not ready? It appears that some biological program can shut down all bodily functions, in much the same way as apoptosis does so at the cellular leve...
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Article
First-in-class antifibrotic therapy targeting type 1 lysophosphatidic acid receptor
Fibrosis is a normal process for repairing injured tissue. However, aberrant or hyperfibrotic responses result in serious pathologic conditions and sometimes life-threatening diseases. A new class of drugs ant...
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Article
Inhibitory effects of antagonistic compounds produced from Lactobacillus brevis MLK27 on adhesion of Listeria monocytogenes KCTC3569 to HT-29 cells
Among lactic acid bacteria (LAB) isolated from mustard leaf kimchi, MLK27 was the most efficient strain in terms of adhesion to HT-29 cells. Competitive, exclusive, and displaceable inhibition of Listeria monocyt...
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Article
Open AccessEffect of Di-(2-ethylhexyl)-phthalate on Sphingolipid Metabolic Enzymes in Rat Liver
Di-(2-ethylhexyl)-phthalate (DEHP), the most widely utilized industrial plastizer and a ubiquitous environmental contaminant, can act on peroxisome proliferators-activated nuclear hormone receptor family (PPAR...
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Article
A promising anti-inflammatory and anti-thrombotic drug for sepsis treatment
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Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors
Previous studies on lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) using various approaches have shown that both the molecules can act as intercellular signaling molecules. The discovery of the ...
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Article
Increase in sphingolipid catabolic enzyme activity during aging
To understand the contribution of sphingolipid metabolism and its metabolites to development and aging.
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Article
Discovery of sphingosine 1-O-methyltransferase in rat kidney and liver homogenates
To characterize sphingosine methyltransferase in rat tissues.
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Article
Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells
To study the effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis, such as wuweizisu C, gomisin N, gomisin A, and schisandrin, on the membrane potential in C6 glioma cells.
