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Open AccessFLT3 inhibitors upregulate CXCR4 and E-selectin ligands via ERK suppression in AML cells and CXCR4/E-selectin inhibition enhances anti-leukemia efficacy of FLT3-targeted therapy in AML
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Open AccessInhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy
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Article
Open AccessDisease modifying and antiangiogenic activity of 2-Methoxyestradiol in a murine model of rheumatoid arthritis
A critical component of disease progression in rheumatoid arthritis (RA) involves neovascularization associated with pannus formation. 2-methoxyestradiol (2ME2) is a naturally occurring molecule with no known ...
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Article
Open AccessENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo
Hepatocellular carcinoma (HCC) represents a highly vascularized tumor entity and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro-angiogenic transcription factors HIF-1α and...
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Article
Rapid, in vivo, evaluation of antiangiogenic and antineoplastic gene products by nonviral transfection of tumor cells
Using a nonviral, electroporation-based gene transfection approach, we demonstrate the efficient and consistent transfection of two poorly immunogenic tumor cell lines: B16F10 melanoma and renal carcinoma (REN...
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Article
Zinc ligand-disrupted recombinant human Endostatin: Potent inhibition of tumor growth, safety and pharmacokinetic profile
Endostatin, a potent endogenous inhibitor of angiogenesis, inhibits the growth of primary tumors without induction of acquired drug resistance in mice. We report that a soluble recombinant human (rh) Endostati...
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Article
Biological characterization of a chimeric mouse-human IgM antibody directed against the 17-1A antigen
A chimeric antibody was constructed in which the murine H- and L-chain variable regions of mAb 17-1A, raised against human colorectal cancer cells, were joined with the human constant μ and κ regions. Transfec...
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Chapter
Circumvention of Neoplastic Heterogeneity by Systemically Activated Macrophages
The continuous growth of metastases that are resistant to conventional therapies is the major cause of death from colorectal carcinoma. Recent data indicate that metastases can arise from the nonrandom spread ...
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Article
Efficient activation of human blood monocytes to a tumoricidal state by liposomes containing human recombinant gamma interferon
Human recombinant gamma interferon (INF-γ) activated human peripheral blood monocytes to a cytotoxic state capable of lysing adherent tumorigenic cells without harming normal cells. The efficiency of INF-γ act...
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Chapter
Role of Macrophages in Host Resistance Against Tumors
The most devastating aspect of cancer is the propensity of malignant neoplasms to spread from their primary site of growth to distant organs where secondary tumors, metastases, can develop. Despite remarkable ...
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Article
Toxicity studies of liposome-encapsulated immunomodulators administered intravenously to dogs and mice
Multilamellar liposomes containing lymphokines from mitogen-stimulated rat lymphocytes were injected IV into BALB/c or (C57BL/6×C3H)F1 mice and Beagle dogs to evaluate their potential toxicity. Animals receive...
