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Article
Open AccessCross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing multiple myeloma
Despite advancements in understanding the pathophysiology of Multiple Myeloma (MM), the cause of rapid progressing disease in a subset of patients is still unclear. MM’s progression is facilitated by complex i...
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Article
Open AccessAblation of VLA4 in multiple myeloma cells redirects tumor spread and prolongs survival
Multiple myeloma (MM) is a cancer of bone marrow (BM) plasma cells, which is increasingly treatable but still incurable. In 90% of MM patients, severe osteolysis results from pathological interactions between ...
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Article
Open AccessA pilot study of 3D tissue-engineered bone marrow culture as a tool to predict patient response to therapy in multiple myeloma
Cancer patients undergo detrimental toxicities and ineffective treatments especially in the relapsed setting, due to failed treatment attempts. The development of a tool that predicts the clinical response of ...
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Article
Utilization of radiation therapy in multiple myeloma: trends and changes in practice
Plasma cell disorders including plasmacytomas and multiple myeloma (MM) are exquisitely radiosensitive, and thus, radiation therapy (XRT) is used effectively in their management. The role of XRT in the setting...
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Article
Open AccessInhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy
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Article
Open AccessA multiple myeloma-specific capture sequencing platform discovers novel translocations and frequent, risk-associated point mutations in IGLL5
Multiple myeloma (MM) is a disease of copy number variants (CNVs), chromosomal translocations, and single-nucleotide variants (SNVs). To enable integrative studies across these diverse mutation types, we devel...
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Article
Open AccessCellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential
Hematopoietic clones harboring specific mutations may expand over time. However, it remains unclear how different cellular stressors influence this expansion. Here we characterize clonal hematopoiesis after tw...
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Article
Similar survival outcomes in patients with biclonal versus monoclonal myeloma: a multi-institutional matched case-control study
Multiple myeloma is a plasma cell malignancy characterized by clonal proliferation of plasma cells in the bone marrow and associated organ damage. Usually, patients with myeloma present with a single monoclona...
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Article
Open AccessPersonalization of cancer treatment using predictive simulation
The personalization of cancer treatments implies the reconsideration of a one-size-fits-all paradigm. This move has spawned increased use of next generation sequencing to understand mutations and copy number a...
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Article
Phase I study of cladribine, cytarabine, granulocyte colony stimulating factor (CLAG regimen) and midostaurin and all-trans retinoic acid in relapsed/refractory AML
We conducted a phase I study using midostaurin (25 or 50 mg orally twice daily), all-trans retinoic acid (ATRA) and CLAG chemotherapy to target multiple pathways in relapsed/refractory AML. 10 patients received t...
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Article
A topological approach to finding grids in calibration patterns
This paper describes a technique for finding regular grids in the images of calibration patterns, a crucial step in calibrating cameras. Corner features located by a corner detector are connected using Delauna...
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Article
Self-identifying patterns for plane-based camera calibration
Determining camera calibration parameters is a time-consuming task despite the availability of calibration algorithms and software. A set of correspondences between points on the calibration target and the cam...
