3 Result(s)

Article

Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy

T-cell-based immunotherapy, such as CAR-T cells and bispecific T-cell engagers (BiTEs), has shown promising clinical outcomes in many cancers; however, these therapies have significant limitations, such as poo...

Kinan Alhallak, Jennifer Sun, Katherine Wasden, Nicole Guenthner, Julie O’Neal… in Leukemia (2021)

Article

Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma

Drug resistance and dose-limiting toxicities are significant barriers for treatment of multiple myeloma (MM). Bone marrow microenvironment (BMME) plays a major role in drug resistance in MM. Drug delivery with...

Cinzia Federico, Kinan Alhallak, Jennifer Sun, Kathleen Duncan… in Nature Communications (2020)

Article

Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy

Barbara Muz, Feda Azab, Mark Fiala, Justin King, Daniel Kohnen… in Blood Cancer Journal (2019)