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A Day in the Life of Guest Experience Stagers: The Saffire Freycinet Experience
This case study illustrates a day in the life of hosts and guests at Saffire Freycinet, a luxury lodge in Tasmania, Australia. It highlights key aspects in the co-creation and management of high quality accomm...
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Article
Autologous stem cell transplant for patients with multiple myeloma between ages 75 and 78
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Article
Open AccessNanoparticle T-cell engagers as a modular platform for cancer immunotherapy
T-cell-based immunotherapy, such as CAR-T cells and bispecific T-cell engagers (BiTEs), has shown promising clinical outcomes in many cancers; however, these therapies have significant limitations, such as poo...
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Article
Open AccessCo-evolution of tumor and immune cells during progression of multiple myeloma
Multiple myeloma (MM) is characterized by the uncontrolled proliferation of plasma cells. Despite recent treatment advances, it is still incurable as disease progression is not fully understood. To investigate...
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Article
Open AccessTumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma
Drug resistance and dose-limiting toxicities are significant barriers for treatment of multiple myeloma (MM). Bone marrow microenvironment (BMME) plays a major role in drug resistance in MM. Drug delivery with...
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Article
Open AccessEvolution and structure of clinically relevant gene fusions in multiple myeloma
Multiple myeloma is a plasma cell blood cancer with frequent chromosomal translocations leading to gene fusions. To determine the clinical relevance of fusion events, we detect gene fusions from a cohort of 74...
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Article
Open AccessInhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy
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The efficacy of salvage autologous stem cell transplant among patients with multiple myeloma who received maintenance therapy post initial transplant
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Article
Open AccessA multiple myeloma-specific capture sequencing platform discovers novel translocations and frequent, risk-associated point mutations in IGLL5
Multiple myeloma (MM) is a disease of copy number variants (CNVs), chromosomal translocations, and single-nucleotide variants (SNVs). To enable integrative studies across these diverse mutation types, we devel...
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Article
Open AccessFire Response to Local Climate Variability: Huascarán National Park, Peru
In Huascarán National Park (HNP), Peru, grazing and anthropogenic burning have been interacting for decades with natural ignitions and climate variability to reconfigure the fire regimes of the vegetative comm...
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Article
Open AccessPersonalization of cancer treatment using predictive simulation
The personalization of cancer treatments implies the reconsideration of a one-size-fits-all paradigm. This move has spawned increased use of next generation sequencing to understand mutations and copy number a...
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Article
Silicon Carbide Waveguides for Optogenetic Neural Stimulation
In this paper we present a microfabricated SiC based alternative to glass-fiber optogenetic stimulation. The glass fiber system currently used for stimulation has numerous drawbacks. First, the very presence o...
