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Article
Open AccessRestricting datasets to classifiable samples augments discovery of immune disease biomarkers
Immunological diseases are typically heterogeneous in clinical presentation, severity and response to therapy. Biomarkers of immune diseases often reflect this variability, especially compared to their regulat...
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Article
Open AccessImmune profile of patients with peritoneal carcinomatosis selected for CRS-HIPEC therapy
Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment option for peritoneal carcinomatosis (PC) from colorectal cancer (CRC), which is otherwise a terminal ...
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Article
Open AccessCharacteristics and outcome of patients with small bowel adenocarcinoma (SBA)
Small bowel adenocarcinoma (SBA) remains a rare malignancy accounting for less than 5% of all the gastrointestinal tract cancers. However, only limited data and expert guidelines are available for this entity....
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Chapter
Lebendspende Lebertransplantation beim Kind und Jugendlichen
Primär widerspricht eine Lebendspende dem ärztlichem Grundsatz primum non nocere. Nicht zuletzt daher sind in Deutschland Organlebendspenden auf ein nur sehr begrenztes Kollektiv naher Angehöriger oder „emotional...
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Article
Open AccessSemiresorbable biologic hybrid meshes for ventral abdominal hernia repair in potentially contaminated settings: lower risk of recurrence
In case of potential contamination, implantation of synthetic meshes in hernia and abdominal wall surgery is problematic due to a higher risk of mesh infection. As an alternative, a variety of different biolog...
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Article
Open AccessResection of oesophageal and oesophagogastric junction cancer liver metastases — a summary of current evidence
Metastatic oesophageal cancer is commonly considered as a palliative situation with a poor prognosis. However, there is increasing evidence that well-selected patients with a limited number of liver metastases...
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Article
Open AccessSuccessful auxiliary two-staged partial resection liver transplantation (ASPIRE-LTx) for end-stage liver disease to avoid small-for-size situations
Risks for living-liver donors are lower in case of a left liver donation, however, due to lower graft volume, the risk for small-for-size situations in the recipients increases. This study aims to prevent smal...
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Article
Open AccessVirus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis
Treatment of advanced melanoma with combined PD-1/CTLA-4 blockade commonly causes serious immune-mediated complications. Here, we identify a subset of patients predisposed to immune checkpoint blockade-related...
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Chapter
Individualisierte Leberchirurgie
In diesem Kapitel wurden die individuelle technischen Besonderheiten und schwierige intraoperative Situationen bei konventionellen und laparoskopischen Hemihepatektomie rechts, eine Hemihepatektomie links sowi...
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Article
Open AccessNegative pressure wound therapy (NPWT) on closed incisions to prevent surgical site infection in high-risk patients in hepatopancreatobiliary surgery: study protocol for a randomized controlled trial—the NP-SSI trial
Incisional surgical site infections (iSSI) in hepatopancreatobiliary (HPB) surgery usually lead to prolonged hospital stays, consume valuable resources, and impact on patients’ outcome. Prophylactic closed inc...
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Article
Association between cardiorespiratory fitness and colorectal cancer in the UK Biobank
Increased cardiorespiratory fitness is related to decreased risk of major chronic illnesses, including cardiovascular disease, type 2 diabetes, and cancer, but its association with colorectal cancer specifical...
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Article
Random gene sets in predicting survival of patients with hepatocellular carcinoma
Despite multiple publications, molecular signatures predicting the course of hepatocellular carcinoma (HCC) have not yet been integrated into clinical routine decision-making. Given the diversity of published ...
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Article
Open AccessTIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity
Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that recipient CD4+ T cell responses are ...
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Article
Open AccessPostoperative cellular stress in the kidney is associated with an early systemic γδ T-cell immune cell response
Basic science data suggest that acute kidney injury (AKI) induced by ischemia-reperfusion injury (IRI) is an inflammatory process involving the adaptive immune response. Little is known about the T-cell contri...
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Article
Laparoscopy as a useful selection tool for patients with prior surgery and peritoneal metastases suitable for multimodality treatment strategies
Complete macroscopic cytoreduction in patients with peritoneal carcinomatosis (PC) is the basic requirement for long-term survival. Diagnostic laparoscopy (DL) can be difficult and of limited clinical value se...
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Article
Open AccessALPPS (associating liver partition and portal vein ligation for staged hepatectomy) does not affect proliferation, apoptosis, or angiogenesis as compared to standard liver resection for colorectal liver metastases
ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a novel two-stage strategy to induce rapid hypertrophy of the future liver remnant (FLR) when patients are in danger of po...
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Article
Morbidity of hepatic resection for intermediate and advanced hepatocellular carcinoma
According to current treatment guidelines, surgical resection of hepatocellular carcinoma (HCC) is mostly restricted to a limited subgroup of patients. Due to improved surgical techniques and perioperative man...
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Article
Open AccessNeuroendocrine tumors of the pancreas: a retrospective single-center analysis using the ENETS TNM-classification and immunohistochemical markers for risk stratification
This study was performed to assess the 2006 introduced ENETS TNM-classification with respect to patient survival and surgical approach for patients who underwent surgery for a neuroendocrine tumor of the pancr...
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Article
Long-term results after in-situ split (ISS) liver resection
In-situ split (ISS) liver resection is a novel method to induce rapid hypertrophy of the contralateral liver lobe in patients at risk for postoperative liver failure due to insufficient liver remnant. So far, ...
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Article
Simplified approach for the assessment of kidney perfusion and acute kidney injury at the bedside using contrast-enhanced ultrasound
