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Open AccessCorrection: Corrigendum: Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes
Nature Communications 7 Article number:11942 (2016); Published 23 June 2016; Updated 21 July 2016 The original version of this Article contained an error in the spelling of the author Luisa Robbez-Masson, whic...
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Open AccessBeta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes
Receptor tyrosine kinases (RTKs) and integrins cooperate to stimulate cell migration and tumour metastasis. Here we report that an integrin influences signalling of an RTK, c-Met, from inside the cell, to prom...
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Article
FAK-heterozygous mice display enhanced tumour angiogenesis
Genetic ablation of endothelial focal adhesion kinase (FAK) can inhibit pathological angiogenesis, suggesting that loss of endothelial FAK is sufficient to reduce neovascularization. Here we show that reduced ...
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Open Accessβ3-integrin is required for differentiation in OC-2 cells derived from mammalian embryonic inner ear
The mammalian inner ear contains the organ of Corti which is responsible for the conversion of sound into neuronal signals. This specialised epithelial tissue is the product of a complex developmental process ...
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Article
A direct role for Met endocytosis in tumorigenesis
Compartmentalization of signals generated by receptor tyrosine kinase (RTK) endocytosis has emerged as a major determinant of various cell functions. Here, using tumour-associated Met-activating mutations, we ...
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Open AccessEP4-mediated prostanoid signalling promotes oral cancer progression
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Article
Erratum: Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome
Nature 465, 813–817 (2010) In this Letter, the address for author Ralf H. Adams was listed incorrectly. The correct address is: Department of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicin...
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Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome
Down's syndrome is caused by the presence of an extra copy of chromosome 21 (a state known as trisomy), and it is known that the growth of certain tumours is reduced in this genetic disorder. A study of a mous...
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Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
Inhibitors of αvβ3 and αvβ5 integrins have previously been shown to inhibit tumor angiogenesis and growth and have entered human clinical trials. Andrew Reynolds and his coworkers now show that low (nanomolar) co...
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Article
Integrin trafficking and its role in cancer metastasis
Enhanced levels of expression of certain integrins, and a consequent increase in specific integrin signals, have been linked to cancer cell progression. Dysfunctional integrin signaling is thought to be involv...
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Article
Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer
Comparison of gene expression changes between cancer cells at the periphery and in the centre of breast cancers was performed using a combination of microdissection and microarray analysis. Cancer cells from t...
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Article
Rapid solid phase synthesis and biodistribution of 18F-labelled linear peptides
A rapid method for radiolabelling short peptides with 18F (t 1/2=109.7 min) for use in positron emission tomography (PET) was developed. Linear peptides (13mers) were synthesised using solid phas...
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Article
Identification of Changes in Gene Expression Associated with Minimal Residual Disease
Minimal residual disease (MRD), the tumour burden which remains after a course of treatment that has resulted in clinical remission [1], appears to differ in certain characteristics from the primary tumour pop...
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Article
Fibronectin is chemotactic for CT 26 colon carcinoma cells: sub-lines selected for increased chemotaxis to fibronectin display decreased tumorigenicity and lung colonization
CT 26 murine colon carcinoma cells demonstrated directional migration (chemotaxis) in response to fibronectin (FN). Sub-lines were derived by positive and negative selection to FN across Transwell filters of 8...
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Article
Selectin ligands on human melanoma cells
Twelve established human melanoma lines were screened for surface expression of the carbohydrate antigens Lewisa (Lea), sialyl Lewisa (SLea), dimeric sialyl Lewisa (diSLea), sialyl LewisX (SLeX) and dimeric sialy...
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Experimental metastasis and differentiation of murine melanoma cells: actions and interactions of factors affecting different intracellular signalling pathways
Various factors that modulate the differentiation of malignant cells are known to affect their experimental metastatic potential (EMP), or lung colonization after intravenous injection into syngeneic animals. .....
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Cell adhesion receptor expression during melanoma progression and metastasis
Many steps in melanoma metastasis involve cell-cell or cell-matrix adhesive interactions. The surface molecules which mediate these processes therefore play an important role in regulating melanoma disseminati...
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Different growth responses to agents which elevate cAMP in human melanoma cell lines of high and low experimental metastatic capacity
Human melanoma variants of low and high experimental metastatic activity, which had been derived from the same parental line, showed markedly different growth responses to agents which elevated intracellular c...
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Enhanced experimental metastatic capacity of a murine melanoma following pre-treatment with anticancer drugs
The effect of in vitro pretreatment of B16 murine melanoma cells with various cancer chemotherapeutic agents on their subsequent experimental metastatic capacity has been examined. Methotrexate, cytosine arabi...
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The Use of Nude Mice to Ascertain the Malignant Capacity of Human Colon Cancer
The metastatic behavior of 14 cell lines derived from 13 individual human tumor cell lines (six of which were colon carcinomas) have been assessed in athymic, nude mice. Many of these lines produced lung metas...
