-
Article
Oral and Poster Papers Submitted for Presentation at the 5th Congress of the EUGMS “Geriatric Medicine in a Time of Generational Shift September 3–6, 2008 Copenhagen, Denmark
-
Article
Human adipose tissue glucose uptake determined using [18F]-fluoro-deoxy-glucose ([18F]FDG) and PET in combination with microdialysis
To determine the lumped constant (LC), which accounts for the differences in the transport and phosphorylation between [18F]-2-fluoro-2-deoxy-d-glucose ([18F]FDG) and glucose, for [18F]FDG in human adipose tissu...
-
Article
Pharmacokinetics of oral entacapone after frequent multiple dosing and effects on levodopa disposition
Objective: Entacapone is a peripherally acting catechol O-methyltransferase (COMT) inhibitor used as an adjunct to each daily levodopa/dopa decarboxylase (DDC) inhibitor dose in the trea...
-
Article
A double-blind study of MPV-2213ad, a novel aromatase inhibitor, in healthy male subjects
Objective: Novel aromatase inhibitors are developed with requirements of high potency and selectivity for the aromatase enzyme. The hormonal effects of a new, non-steroidal competitive i...
-
Article
Aqueous humour concentration and the intraocular pressure-lowering effect of topical betaxolol before cataract surgery
Objective: The aim was to study the relationship between aqueous humour betaxolol concentration and intraocular pressure (IOP).
-
Article
Kinetics of propiverine as assessed by radioreceptor assay in poor and extensive metabolizers of debrisoquine
A pharmacokinetic study with 30 mg propiverine p.o. was performed in healthy volunteers (10 males, 6 females, age 36–56 years, body weight 55–100 kg, body height 162–184 cm, Broca index 0.96–1.19). 8 of them w...
-
Article
The relationship between debrisoquine oxidation phenotype and the pharmacokinetics of chlorpropamide
The pharmacokinetics and urinary metabolite pattern of a single oral dose of chlorpropamide 250 mg have been studied in 6 extensive and 5 poor metabolizers of debrisoquine. Ammonium chloride was given orally t...
-
Article
Prevalence of debrisoquine oxidation phenotypes in glaucoma patients
The oxidation of debrisoquine, a sympatholytic antihypertensive agent, exhibits genetic polymorphism. The debrisoquine/4-OH-debrisoquine metabolic ratio (MR) separates the population to poor (PM, MR>12.6) and ...
-
Article
Effect of guar gum on glipizide absorption in man
The effect of 4.75 g guar gum, a fibre preparation, on the absorption of 2.5 mg glipizide has been studied in 10 healthy volunteers given a standard breakfast. Three different experimental protocols were used:...
-
Article
Effect of guar gum, a fibre preparation, on digoxin and penicillin absorption in man
The effect of guar gum on the absorption of digoxin and phenoxymethyl penicillin was studied in a double blind study in 10 healthy volunteers. Guar gum reduced serum digoxin concentration during the early abso...
-
Article
Roles of chlorpropamide, alcohol and acetaldehyde in determining the chlorpropamide-alcohol flush
The value and reproducibility of the chlorpropamide-alcohol flush (CPAF) have been questioned, and objective measures of the test are required. Recording of facial skin temperature, measurement of chlorpropami...
