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Article
Aqueous humour concentration and the intraocular pressure-lowering effect of topical betaxolol before cataract surgery
Objective: The aim was to study the relationship between aqueous humour betaxolol concentration and intraocular pressure (IOP).
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Article
The effects of transdermal scopolamine on autonomic nervous activity during sleep
We studied the effect of transdermally applied scopolamine (scopolamine-TTS) on autonomic nervous activity during sleep. The double-blind, randomized, crossover study was carried out in six healthy male volunt...
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Article
Receptor binding assays in analysing the bioavailability and pharmacodynamic bioequivalence of active drug moieties
The bioavailability and pharmacodynamic bioequivalence of a conventional and an experimental sustained-release formulation of 100 mg metoprolol tartrate were studied in a randomised cross-over study in seven h...
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Article
Kinetics of propiverine as assessed by radioreceptor assay in poor and extensive metabolizers of debrisoquine
A pharmacokinetic study with 30 mg propiverine p.o. was performed in healthy volunteers (10 males, 6 females, age 36–56 years, body weight 55–100 kg, body height 162–184 cm, Broca index 0.96–1.19). 8 of them w...
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Article
Prevalence of debrisoquine oxidation phenotypes in glaucoma patients
The oxidation of debrisoquine, a sympatholytic antihypertensive agent, exhibits genetic polymorphism. The debrisoquine/4-OH-debrisoquine metabolic ratio (MR) separates the population to poor (PM, MR>12.6) and ...
