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    Pharmacokinetics of oral entacapone after frequent multiple dosing and effects on levodopa disposition

    Objective: Entacapone is a peripherally acting catechol O-methyltransferase (COMT) inhibitor used as an adjunct to each daily levodopa/dopa decarboxylase (DDC) inhibitor dose in the trea...

    J. Rouru, A. Gordin, R. Huupponen, S. Huhtala… in European Journal of Clinical Pharmacology (1999)