87 Result(s)

Article

Fatty fish consumption and risk of latent autoimmune diabetes in adults

It has been suggested that intake of fatty fish may protect against both type 1 and type 2 diabetes. Hypotheses rest on the high marine omega-3 fatty acid eicosapentaenoic acid+docosahexaenoic acid (EPA+DHA) a...

J E Löfvenborg, T Andersson, P-O Carlsson, M Dorkhan, L Groop… in Nutrition & Diabetes (2014)

Article

Common variant in the HMGA2 gene increases susceptibility to nephropathy in patients with type 2 diabetes

Type 2 diabetes is a chronic metabolic disorder associated with devastating microvascular complications. Genome-wide association studies have identified more than 60 genetic variants associated with type 2 dia...

S. Alkayyali, M. Lajer, H. Deshmukh, E. Ahlqvist, H. Colhoun, B. Isomaa… in Diabetologia (2013)

Article

Worse glycaemic control in LADA patients than in those with type 2 diabetes, despite a longer time on insulin therapy

Our aim was to study whether glycaemic control differs between individuals with latent autoimmune diabetes in adults (LADA) and patients with type 2 diabetes, and whether it is influenced by time on insulin th...

C. D. Andersen, L. Bennet, L. Nyström, U. Lindblad, E. Lindholm, L. Groop… in Diabetologia (2013)

Article

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with...

A. Albrechtsen, N. Grarup, Y. Li, T. Sparsø, G. Tian, H. Cao, T. Jiang… in Diabetologia (2013)

Article

Effect of a common variant of the PCSK2 gene on reduced insulin secretion

Individuals at risk of develo** type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time. However, inability of the beta cells to compensate for the increase...

A. Jonsson, B. Isomaa, T. Tuomi, J. G. Eriksson, L. Groop, V. Lyssenko in Diabetologia (2012)

Article

SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes

Parental type 2 diabetes mellitus increases the risk of diabetic nephropathy in offspring with type 1 diabetes mellitus. Several single nucleotide polymorphisms (SNPs) that predispose to type 2 diabetes mellit...

E. Fagerholm, E. Ahlqvist, C. Forsblom, N. Sandholm, A. Syreeni… in Diabetologia (2012)

Article

γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes

γ-Aminobutyric acid (GABA) is a signalling molecule in the interstitial space in pancreatic islets. We examined the expression and function of the GABA signalling system components in human pancreatic islets f...

J. Taneera, Z. **, Y. **, S. J. Muhammed, E. Zhang, S. Lang, A. Salehi… in Diabetologia (2012)

Article

A common variant upstream of the PAX6 gene influences islet function in man

Impaired glucose tolerance and impaired insulin secretion have been reported in families with PAX6 mutations and it is suggested that they result from defective proinsulin processing due to lack of prohormone con...

E. Ahlqvist, F. Turrini, S. T. Lang, J. Taneera, Y. Zhou, P. Almgren… in Diabetologia (2012)

Article

Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study

To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland.

P. Almgren, M. Lehtovirta, B. Isomaa, L. Sarelin, M. R. Taskinen… in Diabetologia (2011)

Article

A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes

An accurate molecular diagnosis of diabetes subtype confers clinical benefits; however, many individuals with monogenic diabetes remain undiagnosed. Biomarkers could help to prioritise patients for genetic inv...

G. Thanabalasingham, N. Shah, M. Vaxillaire, T. Hansen, T. Tuomi… in Diabetologia (2011)

Article

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA_1c levels in human pancreatic islets

Although recent studies propose that epigenetic factors influence insulin expression, the regulation of the insulin gene in type 2 diabetic islets is still not fully understood. Here, we examined DNA methylati...

B. T. Yang, T. A. Dayeh, C. L. Kirkpatrick, J. Taneera, R. Kumar, L. Groop… in Diabetologia (2011)

Article

Evidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: a follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish Twin Cohort Study

We investigated whether BMI predicts type 2 diabetes in twins and to what extent that is explained by common genetic factors.

M. Lehtovirta, K. H. Pietiläinen, E. Levälahti, K. Heikkilä, L. Groop… in Diabetologia (2010)

Article

Erratum to: Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 finnish adults

A. Jonsson, F. Renström, V. Lyssenko, E. C. Brito, B. Isomaa, G. Berglund… in Diabetologia (2010)

Article

Erratum to: An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics

A. Tura, S. Sbrignadello, E. Succurro, L. Groop, G. Sesti, G. Pacini in Diabetologia (2010)

Article

Analysis of TBC1D4 in patients with severe insulin resistance

S. Dash, C. Langenberg, K. A. Fawcett, R. K. Semple, S. Romeo, S. Sharp… in Diabetologia (2010)

Article

Prediction of postpartum diabetes in women with gestational diabetes mellitus

We studied the incidence of postpartum diabetes after gestational diabetes mellitus and investigated biochemical and clinical predictors of postpartum diabetes.

M. Ekelund, N. Shaat, P. Almgren, L. Groop, K. Berntorp in Diabetologia (2010)

Article

Genetic association analysis of LARS2 with type 2 diabetes

LARS2 has been previously identified as a potential type 2 diabetes susceptibility gene through the low-frequency H324Q (rs71645922) variant (minor allele frequency [MAF] 3.0%). Howeve...

E. Reiling, B. Jafar-Mohammadi, E. van ’t Riet, M. N. Weedon… in Diabetologia (2010)

Article

An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics

Minimal model analysis for insulin sensitivity has been validated against the glucose clamp and is an accepted method for estimating insulin sensitivity from IVGTT. However minimal model analysis requires a 3 ...

A. Tura, S. Sbrignadello, E. Succurro, L. Groop, G. Sesti, G. Pacini in Diabetologia (2010)

Article

Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults

Recent reports have suggested that genotypes at the FTO locus interact with physical activity to modify levels of obesity-related traits. We tested this hypothesis in two non-diabetic population-based cohorts, th...

A. Jonsson, F. Renström, V. Lyssenko, E. C. Brito, B. Isomaa, G. Berglund… in Diabetologia (2009)

Article

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men

We studied the physiological, metabolic and hormonal mechanisms underlying the elevated risk of type 2 diabetes in carriers of TCF7L2 gene.

K. Pilgaard, C. B. Jensen, J. H. Schou, V. Lyssenko, L. Wegner, C. Brøns… in Diabetologia (2009)