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  1. Article

    Open Access

    Basal and cold-induced fatty acid uptake of human brown adipose tissue is impaired in obesity

    Fatty acids (FA) are important substrates for brown adipose tissue (BAT) metabolism, however, it remains unclear whether there exists a difference in FA metabolism of BAT between lean and obese healthy humans....

    T. J. Saari, J. Raiko, M. U-Din, T. Niemi, M. Taittonen, J. Laine… in Scientific Reports (2020)

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  2. No Access

    Article

    Adipose tissue mitochondrial capacity associates with long-term weight loss success

    We investigated whether (1) subcutaneous adipose tissue (SAT) mitochondrial capacity predicts weight loss success and (2) weight loss ameliorates obesity-related SAT mitochondrial abnormalities.

    R Jokinen, R Rinnankoski-Tuikka, S Kaye, L Saarinen… in International Journal of Obesity (2018)

  3. No Access

    Article

    Subcutaneous adipose tissue gene expression and DNA methylation respond to both short- and long-term weight loss

    Few studies have examined both gene expression and DNA methylation profiles in subcutaneous adipose tissue (SAT) during long-term weight loss. Thus, molecular mechanisms in weight loss and regain remain elusive.

    S Bollepalli, S Kaye, S Heinonen, J Kaprio, A Rissanen… in International Journal of Obesity (2018)

  4. No Access

    Article

    Impact of a very low-energy diet on the fecal microbiota of obese individuals

    Study how the dietary intake affects the fecal microbiota of a group of obese individuals after a 6-week very low-energy diet (VLED) and thereafter during a follow-up period of 5, 8, and 12 months. Additional...

    C. D. Simões, J. Maukonen, K. P. Scott, K. A. Virtanen… in European Journal of Nutrition (2014)

  5. Article

    Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver

    We investigated the effect of elevated circulating NEFA on insulin-mediated hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male subjects.

    P. Iozzo, R. Lautamaki, F. Geisler, K. A. Virtanen, V. Oikonen… in Diabetologia (2004)

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  6. Article

    Human adipose tissue glucose uptake determined using [18F]-fluoro-deoxy-glucose ([18F]FDG) and PET in combination with microdialysis

    To determine the lumped constant (LC), which accounts for the differences in the transport and phosphorylation between [18F]-2-fluoro-2-deoxy-d-glucose ([18F]FDG) and glucose, for [18F]FDG in human adipose tissu...

    K. A. Virtanen, P. Peltoniemi, P. Marjamäki, M. Asola, L. Strindberg… in Diabetologia (2001)

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