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Article
Impact of ABCC2 haplotypes on transcriptional and posttranscriptional gene regulation and function
ABCC2 (MRP2) is an important export pump, expressed at tissue barriers. The genetic variants −24C>T, 1249G>A and 3972C>T are leading to inter-individual differences of bioavailability of various endogenous and...
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Article
Persistierendes Fieber unter zielgerichteter antituberkulotischer Therapie
Ein 37-jähriger Inder wurde mit persistierendem Husten und hohem Fieber stationär aufgenommen. Umfassende Untersuchungen sicherten die Diagnose einer Lungentuberkulose. Die kalkulierte antituberkulöse Therapie...
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Article
ABSTRACTS: ISoP Annual Conference ‘Joining Forces for Managing Risks’ Liège, Belgium 11–13 October, 2006
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Article
ABSTRACTS: ISoP Annual Conference ‘Joining Forces for Managing Risks’ Liège, Belgium 11–13 October, 2006
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Article
223 Placental Transfer of the Protease Inhibitor Nelfinavir in the Dual in Vitro Placenta Perfusion Model
Intro: The protease inhibitor nelfinavir is a common drug for treatment of HIV in pregnancy. Pairs of serum samples of maternal vein - and umbilical cord blood show very low levels of nelfinavir in umbilical c...
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Article
Arzneimitteltransporter
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Schmerztherapie
Es war schon immer die wichtigste Aufgabe des Arztes, Leiden vom Patienten abzuwenden oder zumindest zu lindern. So umfaßt der Kernbereich der anästhesiologischen Tätigkeit die Bekämpfung von Schmerzen.
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Article
Kinetics of propiverine as assessed by radioreceptor assay in poor and extensive metabolizers of debrisoquine
A pharmacokinetic study with 30 mg propiverine p.o. was performed in healthy volunteers (10 males, 6 females, age 36–56 years, body weight 55–100 kg, body height 162–184 cm, Broca index 0.96–1.19). 8 of them w...
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Article
Level- and line-crossing in forward scattering and selective reflection in a transverse magnetic field
LC-experiments in forward scattering and selective reflection are mostly performed in a longitudinal magnetic field. We have extended the investigations to a transverse field receiving the following results. T...
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Article
Excitation of orientation and alignment by unpolarized light
The experimental arrangements to generate all tensor components of orientation and alignment are outlined. For different cases calculated and measured curves are shown. Whereas in the case of alignment the con...