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Article
Neuigkeiten und Perspektiven der Neurointensivmedizin
Die Neurointensivmedizin ist ein sich ständig weiterentwickelnder Teilbereich der Neurofächer, dessen Anwendung nachweislich zu Verbesserungen des Überlebens und des klinischen Ergebnisses bei Patienten mit sc...
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Article
Standards of Scoring, Monitoring, and Parameter Targeting in German Neurocritical Care Units: A National Survey
Optimal management of physiological parameters in neurological/neurosurgical intensive care units (NICUs) is largely unclear as high-quality evidence is lacking. The aim of this survey was to investigate if st...
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Chapter and Conference Paper
Cerebral Microdialysis in Acutely Brain-Injured Patients with Spreading Depolarizations
Multimodal cerebral monitoring was utilized to examine the relationship between pathological changes in microdialysis parameters and the occurrence of spreading depolarizations (SD) in brain-injured patients. ...
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Chapter
Multiparametric Characterisation of the Perihemorrhagic Zone in a Porcine Model of Lobar ICH
Objectives: To describe early perihemorrhagic changes after lobar intracerebral hemorrhage (ICH) using multiparametric neuromonitoring [intracranial pressure (ICP), cerebral blood flow (CBF), tis...
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Article
Neuromonitoring
Die Dynamik verschiedener spezifischer Parameter, wie z. B. des intrakraniellen Drucks, der zerebralen Oxygenierung und der zerebralen Perfusion, ist von entscheidender Bedeutung für die Prognose bei Patienten...
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Article
Intrakranielle Druck-Volumen-Beziehung
Die posttraumatische Hirndrucksteigerung hat einen signifikanten Einfluss auf die Prognose nach einem Schädel-Hirn-Trauma. Nach Ausschöpfung sämtlicher Kompensationsmöglichkeiten steigt der Hirndruck exponenti...
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Chapter and Conference Paper
Serial diffusion and perfusion MRI analysis of the perihemorrhagic zone in a rat ICH model
Cerebral ischemia has been proposed as a contributing mechanism to secondary neuronal injury after intracranial hemorrhage (ICH). We aimed to examine perihemorrhagic changes with an animal experimental MRI stu...
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Chapter
Erhöhter intrakranieller Druck
Der Inhalt des Neurokraniums besteht aus dem weichen Hirngewebe, den bindegewebigen Hirnhäuten und -gefäßen (kompressibles Kompartiment) sowie den Flüssigkeiten Liquor und Blut (inkompressibles Kompartiment). ...
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Article
An unusual case of a highly progressive supratentorial capillary haemangioblastoma – histopathological considerations
We describe a case of a rapidly progressive, sporadic, non-von Hippel-Lindau (VHL) disease associated supratentorial capillary haemangioblastoma. Despite the classical histopathological presentation consisting...
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Chapter and Conference Paper
Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact
Granulocyte colony-stimulating factor (G-CSF) is an established treatment in the neutropenic host. Usage in headinjured patients at risk for infection may aggravate brain damage. In contrast, evidence of G-CSF...
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Article
Differential effects of prolonged isoflurane anesthesia on plasma, extracellular, and CSF glutamate, neuronal activity, 125I-Mk801 NMDA receptor binding, and brain edema in traumatic brain-injured rats
Background. Volatile anesthetics reduce neuronal excitation and cerebral metabolism but can also increase intracellular water accumulation in normal and injured brains. While attenuation of neuronal excitation an...
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Chapter and Conference Paper
Neuronal activity and cortical perfusion determined by quantitative EEG analysis and laser Doppler flowmetry are uncoupled in brain injured rats
Following traumatic brain injury uncoupling of metabolism from perfusion, reflected by an increase in cellular activity in face of reduced perfusion contributes to secondary tissue damage.
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Chapter
Erhöhter intrakranieller Druck
Der Inhalt des Neurokrniums besteht uas weichen Hirngewebe, den bindegewebigen Hirnhäuten und -gefäßen (kompressibles Kompartiment) sowie den Flüssigkeiten Liquor und Blut (inkompressibles Kompartiment). Bei...
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Chapter and Conference Paper
Detection of Secondary Insults by Brain Tissue pO2 and Bedside Microdialysis in Severe Head Injury
We evaluated bedside cerebral on-line microdialysis for early detection of cerebral hypoxia in patients with traumatic brain injury. 24 severely head injured patients (Glasgow Coma Score ≤ 8) were studied. Pat...
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Chapter and Conference Paper
Norepinephrine is Superior to Dopamine in Increasing Cortical Perfusion Following Controlled Cortical Impact Injury in Rats
Following traumatic brain injury catecholamines are routinely applied to increase cerebral perfusion. To date, it remains controversial if infusion of catecholamines is associated with diminished cerebral perf...
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Chapter and Conference Paper
Neuronal Activity Determined by Quantitative EEG and Cortical Microdialysis is Increased Following Controlled Cortical Impact Injury in Rats
Following brain injury increased glutamate release is linked to sustained neuronal activation resulting in excitotoxic tissue damage. Isoflurane anesthesia has been shown to decrease electroencephalo-graphic (...
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Chapter and Conference Paper
Time Course of Various Interstitial Metabolites Following Subarachnoid Hemorrhage Studied by on-Line Microdialysis
Subarachnoid hemorrhage (SAH) is one of the most devastating of all cerebrovascular disorders [10]. One of the most serious complications of SAH remains vasospasm [3, 9]. Bedside cerebral microdialysis is a recen...