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Chapter and Conference Paper
Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact
Granulocyte colony-stimulating factor (G-CSF) is an established treatment in the neutropenic host. Usage in headinjured patients at risk for infection may aggravate brain damage. In contrast, evidence of G-CSF...
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Article
Anesthesia increases circulating glutamate in neurosurgical patients
Background. The excitotoxic amino acid glutamate is known to aggravate pre-existing neuropathology. Since volatile anesthetics increase plasma amino acid levels, we investigated if the anesthetics isoflurane and ...
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Chapter and Conference Paper
The antioxidant effect of N-acethylcysteine on experimental contusion in rats
N-acethylcysteine (NAC) is known to have direct and indirect antioxidant abilities. We investigated the potential protective effect of NAC on ICP, brain edema and contusion volume after Controlled Cortical Imp...
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Chapter and Conference Paper
Assessment of the relationship between age and continuous intracranial compliance
The aim of this open, descriptive and prospective study was to determine if the new monitoring parameter “continuous intracranial compliance (cICC)” decreases with age in patients with traumatic brain injury (...
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Article
Differential effects of prolonged isoflurane anesthesia on plasma, extracellular, and CSF glutamate, neuronal activity, 125I-Mk801 NMDA receptor binding, and brain edema in traumatic brain-injured rats
Background. Volatile anesthetics reduce neuronal excitation and cerebral metabolism but can also increase intracellular water accumulation in normal and injured brains. While attenuation of neuronal excitation an...
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Chapter and Conference Paper
Temporal Profiles of Extracellular Nitric Oxide Metabolites Following Aneurysmal Subarachnoid Hemorrhage
The temporal profile of nitric oxide metabolite concentrations i.e. nitrite and nitrate (NO x ) was investigated in brain parenchyma of patients following aneurysmal subarachnoid...
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Article
Barbiturate coma may promote reversible bone marrow suppression in patients with severe isolated traumatic brain injury
Objectives: Barbiturate coma is employed in brain-injured patients whenever increases in intracranial pressure remain unresponsive to less aggressive therapeutic regimens. Barbiturate-me...
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Article
Neurochemical alterations and current pharmacological strategies in the treatment of traumatic brain injury