Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact

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Brain Edema XIII

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 96))

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References

  1. Berezovskaya O, Maysinger D, Fedoroff S (1996) Colony stimulating factor-1 potentiates neuronal survival in cerebral cortex ischemic lesion. Acta Neuropathol (Berl) 92: 479–486

    Article  PubMed  CAS  Google Scholar 

  2. Bramlett HM, Dietrich WD (2004) Pathophysiology of cerebral ischemia and brain trauma: similarities and differences. J Cereb Blood Flow Metab 24: 133–150

    Article  PubMed  Google Scholar 

  3. Brines ML, Ghezzi P, Keenan S, Agnello D, de Lanerolle NC, Cerami C, Itri LM, Cerami A (2000) Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 97: 10526–10531

    Article  PubMed  CAS  Google Scholar 

  4. Chen J, Zhang ZG, Li Y, Wang L, Xu YX, Gautam SC, Lu M, Zhu Z, Chopp M (2003) Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res 92: 692–699

    Article  PubMed  CAS  Google Scholar 

  5. Chopp M, Li Y (2002) Treatment of neural injury with marrow stromal cells. Lancet Neurol 1: 92–100

    Article  PubMed  Google Scholar 

  6. Gibson CL, Bath PM, Murphy SP (2005) G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 25: 431–439

    Article  PubMed  CAS  Google Scholar 

  7. Heard SO, Fink MP, Gamelli RL, Solomkin JS, Joshi M, Trask AL, Fabian TC, Hudson LD, Gerold KB, Logan ED (1998) Effect of prophylactic administration of recombinant human granulocyte colony-stimulating factor (filgrastim) on the frequency of nosocomial infections in patients with acute traumatic brain injury or cerebral hemorrhage. The Filgrastim Study Group. Crit Care Med 26: 748–754

    Article  PubMed  CAS  Google Scholar 

  8. Hill CP, Osslund TD, Eisenberg D (1993) The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors. Proc Natl Acad Sci USA 90: 5167–5171

    Article  PubMed  CAS  Google Scholar 

  9. Keller P, Smalling R (1993) Granulocyte colony stimulating factor: animal studies for risk assessment. Int Rev Exp Pathol 34 Pt A: 173–188

    PubMed  Google Scholar 

  10. Kleinschnitz C, Schroeter M, Jander S, Stoll G (2004) Induction of granulocyte colony-stimulating factor mRNA by focal cerebral ischemia and cortical spreading depression. Brain Res Mol Brain Res 131: 73–78

    Article  PubMed  CAS  Google Scholar 

  11. Malipiero UV, Frei K, Fontana A (1990) Production of hemopoietic colony-stimulating factors by astrocytes. J Immunol 144:3816–3821

    PubMed  CAS  Google Scholar 

  12. McLay RN, Kimura M, Banks WA, Kastin AJ (1997) Granulocyte-macrophage colony-stimulating factor crosses the blood-brain and blood-spinal cord barriers. Brain 120: 2083–2091

    Article  PubMed  Google Scholar 

  13. Park HK, Chu K, Lee ST, Jung KH, Kim EH, Lee KB, Song YM, Jeong SW, Kim M, Roh JK (2005) Granulocyte colonystimulating factor induces sensorimotor recovery in intracerebral hemorrhage. Brain Res 1041: 125–131

    Article  PubMed  CAS  Google Scholar 

  14. Schabitz WR, Kollmar R, Schwaninger M, Juettler E, Bardutzky J, Scholzke MN, Sommer C, Schwab S (2003) Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 34: 745–751

    Article  PubMed  Google Scholar 

  15. Sheibani N, Grabowski EF, Schoenfeld DA, Whalen MJ (2004) Effect of granulocyte colony-stimulating factor on functional and histopathologic outcome after traumatic brain injury in mice. Crit Care Med 32: 2274–2278

    PubMed  CAS  Google Scholar 

  16. Shyu WC, Lin SZ, Yang HI, Tzeng YS, Pang CY, Yen PS, Li H (2004) Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells. Circulation 110: 1847–1854

    Article  PubMed  CAS  Google Scholar 

  17. Stover JF, Unterberg AW (2000) Increased cerebrospinal fluid glutamate and taurine concentrations are associated with traumatic brain edema formation in rats. Brain Res 875: 51–55

    Article  PubMed  CAS  Google Scholar 

  18. Wesselingh SL, Gough NM, Finlay-Jones JJ, McDonald PJ (1990) Detection of cytokine mRNA in astrocyte cultures using the polymerase chain reaction. Lymphokine Res 9: 177–185

    PubMed  CAS  Google Scholar 

  19. Whalen MJ, Carlos TM, Wisniewski SR, Clark RS, Mellick JA, Marion DW, Kochanek PM (2000) Effect of neutropenia and granulocyte colony stimulating factor-induced neutrophilia on blood-brain barrier permeability and brain edema after traumatic brain injury in rats. Crit Care Med 28: 3710–3717

    Article  PubMed  CAS  Google Scholar 

  20. Willing AE, Vendrame M, Mallery J, Cassady CJ, Davis CD, Sanchez-Ramos J, Sanberg PR (2003) Mobilized peripheral blood cells administered intravenously produce functional recovery in stroke. Cell Transplant 12: 449–454

    PubMed  Google Scholar 

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Sakowitz, O.W., Schardt, C., Neher, M., Stover, J.F., Unterberg, A.W., Kiening, K.L. (2006). Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact. In: Hoff, J.T., Keep, R.F., **, G., Hua, Y. (eds) Brain Edema XIII. Acta Neurochirurgica Supplementum, vol 96. Springer, Vienna. https://doi.org/10.1007/3-211-30714-1_31

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  • DOI: https://doi.org/10.1007/3-211-30714-1_31

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-30712-0

  • Online ISBN: 978-3-211-30714-4

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