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Article
Intrazerebrale Blutungen unter oraler Antikoagulation
Das Auftreten einer intrazerebralen Blutung unter oraler Antikoagulation ist mit einer hohen Mortalität und einem ungünstigem neurologischem Outcome assoziiert. Eine herabgesetzte Koagulabilität muss frühzeiti...
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Article
Schädel-Hirn-Trauma unter antithrombotischer Medikation
Störungen der Hämostase stellen bei traumatischen intrakraniellen Blutungen entscheidende Risikofaktoren für ein schlechtes Outcome sowie eine erhöhte Mortalität dar. Im Rahmen eines Polytraumas mit großen Blu...
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Article
Schweres Schädel-Hirn-Trauma
Das Schädel-Hirn-Trauma ist eine der häufigsten Ursachen von Morbidität und Mortalität, insbesondere in der Altersgruppe unter 45 Jahren. Der primäre Hirnschaden entsteht zum Zeitpunkt des Traumas als direkte ...
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Article
Hemangiopericytomas grade II are not benign tumors
Hemangiopericytomas (HPs) of the central nervous system are rare tumors and afflicted with a high propensity of recurrences and metastases. Histopathologically, HPs correspond to differentiated (WHO grade II) ...
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Chapter and Conference Paper
Cerebral Microdialysis in Acutely Brain-Injured Patients with Spreading Depolarizations
Multimodal cerebral monitoring was utilized to examine the relationship between pathological changes in microdialysis parameters and the occurrence of spreading depolarizations (SD) in brain-injured patients. ...
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Article
Transorbital penetrating head injury by a toilet brush handle
Transorbital penetrating brain injuries are rare lesions without defined therapy standards.
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Article
Intrakranielle Druck-Volumen-Beziehung
Die posttraumatische Hirndrucksteigerung hat einen signifikanten Einfluss auf die Prognose nach einem Schädel-Hirn-Trauma. Nach Ausschöpfung sämtlicher Kompensationsmöglichkeiten steigt der Hirndruck exponenti...
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Chapter and Conference Paper
Quantification of transient ischemic and metabolic events in patients after subarachnoid haemorrhage
Secondary insults after brain injury are preventable and/or treatable events affecting patients’ morbidity and mortality. Multimodal cerebral monitoring may allow one to detect such otherwise occult transient ...
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Chapter
Erhöhter intrakranieller Druck
Der Inhalt des Neurokraniums besteht aus dem weichen Hirngewebe, den bindegewebigen Hirnhäuten und -gefäßen (kompressibles Kompartiment) sowie den Flüssigkeiten Liquor und Blut (inkompressibles Kompartiment). ...
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Book
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Chapter and Conference Paper
Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact
Granulocyte colony-stimulating factor (G-CSF) is an established treatment in the neutropenic host. Usage in headinjured patients at risk for infection may aggravate brain damage. In contrast, evidence of G-CSF...
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Chapter and Conference Paper
The antioxidant effect of N-acethylcysteine on experimental contusion in rats
N-acethylcysteine (NAC) is known to have direct and indirect antioxidant abilities. We investigated the potential protective effect of NAC on ICP, brain edema and contusion volume after Controlled Cortical Imp...
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Chapter and Conference Paper
Assessment of the relationship between age and continuous intracranial compliance
The aim of this open, descriptive and prospective study was to determine if the new monitoring parameter “continuous intracranial compliance (cICC)” decreases with age in patients with traumatic brain injury (...
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Chapter and Conference Paper
Cerebral metabolism and intracranial hypertension in high grade aneurysmal subarachnoid haemorrhage patients
We evaluated the effect of intracranial hypertension on cerebral metabolism in patients with high grade aneurysmal subarachnoid hemorrhage (SAH) using bedside cerebral microdialysis (MD). Thirty-six patients w...
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Article
Differential effects of prolonged isoflurane anesthesia on plasma, extracellular, and CSF glutamate, neuronal activity, 125I-Mk801 NMDA receptor binding, and brain edema in traumatic brain-injured rats
Background. Volatile anesthetics reduce neuronal excitation and cerebral metabolism but can also increase intracellular water accumulation in normal and injured brains. While attenuation of neuronal excitation an...
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Chapter and Conference Paper
Neuronal activity and cortical perfusion determined by quantitative EEG analysis and laser Doppler flowmetry are uncoupled in brain injured rats
Following traumatic brain injury uncoupling of metabolism from perfusion, reflected by an increase in cellular activity in face of reduced perfusion contributes to secondary tissue damage.
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Chapter
Erhöhter intrakranieller Druck
Der Inhalt des Neurokrniums besteht uas weichen Hirngewebe, den bindegewebigen Hirnhäuten und -gefäßen (kompressibles Kompartiment) sowie den Flüssigkeiten Liquor und Blut (inkompressibles Kompartiment). Bei...
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Chapter
Spezielle Therapie bei Subarachnoidalblutung
Despie substantial improvement in the management of patients with aneurysmal subarachnoid hemorrhage (SAH), including early aneurysm sugery, endovascular techniques, and neurointensive care, a significant perc...
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Article
Spezielle Therapie bei Subarachnoidalblutung
Despite substantial improvement in the management of patients with aneurysmal subarachnoid hemorrhage (SAH), including early aneurysm sugery, endovascular techniques, and neurointensive care, a significant pe...
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Chapter and Conference Paper
Detection of Secondary Insults by Brain Tissue pO2 and Bedside Microdialysis in Severe Head Injury
We evaluated bedside cerebral on-line microdialysis for early detection of cerebral hypoxia in patients with traumatic brain injury. 24 severely head injured patients (Glasgow Coma Score ≤ 8) were studied. Pat...
