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  1. No Access

    Chapter and Conference Paper

    The antioxidant effect of N-acethylcysteine on experimental contusion in rats

    N-acethylcysteine (NAC) is known to have direct and indirect antioxidant abilities. We investigated the potential protective effect of NAC on ICP, brain edema and contusion volume after Controlled Cortical Imp...

    U. -W. Thomale, M. Griebenow… in Intracranial Pressure and Brain Monitoring… (2005)

  2. No Access

    Article

    Differential effects of prolonged isoflurane anesthesia on plasma, extracellular, and CSF glutamate, neuronal activity, 125I-Mk801 NMDA receptor binding, and brain edema in traumatic brain-injured rats

    Background. Volatile anesthetics reduce neuronal excitation and cerebral metabolism but can also increase intracellular water accumulation in normal and injured brains. While attenuation of neuronal excitation an...

    J. F. Stover, O. W. Sakowitz, S. N. Kroppenstedt, U. W. Thomale… in Acta Neurochirurgica (2004)

  3. No Access

    Chapter and Conference Paper

    Norepinephrine is Superior to Dopamine in Increasing Cortical Perfusion Following Controlled Cortical Impact Injury in Rats

    Following traumatic brain injury catecholamines are routinely applied to increase cerebral perfusion. To date, it remains controversial if infusion of catecholamines is associated with diminished cerebral perf...

    S.-N. Kroppenstedt, O. W. Sakowitz… in Intracranial Pressure and Brain Biochemica… (2002)

  4. No Access

    Chapter and Conference Paper

    Cortical Hypoperfusion Precedes Hyperperfusion Following Controlled Cortical Impact Injury

    Impaired cerebral perfusion contributes to tissue damage following traumatic brain injury. In this longitudinal study persistence of reduced cortical perfusion employing laser doppler flowmetry was investigate...

    U.-W. Thomale, K. Schaser… in Intracranial Pressure and Brain Biochemica… (2002)

  5. No Access

    Article

    Neuroprotective Effect of Melatonin on Cortical Impact Injury in the Rat

    A. S. Sarrafzadeh, U.-W. Thomale, S.-N. Kroppenstedt… in Acta Neurochirurgica (2000)

  6. No Access

    Chapter and Conference Paper

    Isoflurane Doubles Plasma Glutamate and Increases Posttraumatic Brain Edema

    Increased plasma and cerebral glutamate levels may contribute to posttraumatic edema formation. Since volatile anesthetics elevate plasma amino acid concentrations, the influence of isoflurane on arterial plas...

    M.D. J. F. Stover, S. N. Kroppenstedt, U. W. Thomale, O. S. Kempski… in Brain Edema XI (2000)