Abstract
Following traumatic brain injury uncoupling of metabolism from perfusion, reflected by an increase in cellular activity in face of reduced perfusion contributes to secondary tissue damage.
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Back T. Zhao W, Ginsberg MD (1995) Three-dimensional image analysis of brain glucose metabolism-blood flow uncoupling and its electrophysiological correlate in the acute ischemic penumbra following middle cerebral artery occlusion. J Cereb Blood Flow Metab 15: 566–577
Bruehl C Hagemann G, Witte OW (1998) Uncoupling of blood flow and metabolism in focal epilepsy. Epilepsia 39: 1235–1242
Chen Q, Choppp M, Bodzin G, Chen H (1993) Temperature modulation of cerebral depolarization during focal cerebral ischemia in rats: correlation with ischemic injury. J Cereb Blood Flow Metab 13: 389–394
Ginsberg MD, Smith DW, Wachtel MS, Gonzalez-Carvajal M, Busto R (1986) Simultaneous determination of local cerebral glucose utilization and blood flow by carbon-14 double-label autoradiography: method of procedure and validation studies in the rat. J Cereb Blood Flow Metab 6: 273–285
Ginsberg MD, Zhao W, Alonso OF, Loor-Estades JY, Dietrich WD, Busto R (1997) Uncoupling of local cerebral glucose metabolism and blood flow after acute fluid-percussion injury in rats. Am J Physiol 272: H2859–H2868
Golding EM, Robertson CS, Bryan RM (1999) The consequences of traumatic brain injury on cerebral blood flow and autoregulation: a review. Clin Exp Hypertension 21: 299–332
Iijima T, Mies G, Hossmann K-A (1992) Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: effect on volume of ischemic injury. J Cereb Blood Flow Metab 12: 727–733
Kawamata T, Katayama Y, Hovda DA, Yoshino A, Becker DP (1992) Administration of excitatory amino acid antagonists via microdialysis attenuates the increase in glucose utilization seen following concussive brain injury. J Cereb Blood Flow Metab 12: 12–24
Kelly DF, Kozlowski DA, Haddad E, Echiverri A, Hovda DA, Lee SM (2000) Ethanol reduces metabolic uncoupling following experimental head injury. J Neurotrauma 17: 261–272
Kroppenstedt SN, Stover JF, Unterberg AW (2000) Effects of dopamine on posttraumatic cerebral blood flow, brain edema, and cerebrospinal fluid glutamate and hypoxanthine concentrations. Crit Care Med 28: 3792–3798
Liachenko S, Tang P, Somogyi GT, Xu Y (1999) Concentrationdependent isoflurane effects on depolarization-evoked glutamate and GABA outflows from mouse brain slices. Br J Pharmacol 127:131–138
Maclver B, Mikulec AA, Amagasu SM, Monroe VA (1996) Volatile anesthetics depress glutamate transmission via presynaptic actions. Anesthesiology 85: 823–834
Mitani A, Namba S, Ikemune K, Yanase H, Arai T, Kataoka K (1998) Postischemic enhancements of N-Methyl-D-Aspartic Acid (NMDA) and non-NMDA receptor-mediated responses in hippocampal CA1 pyramidal neurons. J Cereb Blood Flow Metab 18: 1088–1098
Nilsson P, Hillered L, Ponten U, Ungerstedt U (1990) Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury. J Cereb Blood Flow Metab 10: 631–637
Nilsson P, Ronne-Engström E, Flink R, Ungerstedt U, Carlson H, Hillered L (1994) Epileptic seizure activity in the acute phase following cortical impact trauma in rat. Brain Res 637: 227–232
Patel PM, Drummond JC, Cole DJ, Goskowicz RL (1995) Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia. Anesthesiology 82: 996–1003
Singh NC, Kochanek PM, Schiding JK, Melick JA, Nemoto EM (1992) Uncoupled cerebral blood flow and metabolism after severe global ischemia in rats. J Cereb Blood Flow Metab 12: 802–808
Stover JF, Schoning B, Beyer TF, Woiciechowsky C, Unterberg AW (2000) Temporal profile of cerebrospinal fluid glutamate, interleukin-6, and tumor necrosis factor-alpha in relation to brain edema and contusion following controlled cortical impact injury in rats. Neurosci Lett 288: 25–28
Sutton RL, Hovda DA, Adelson PD, Benzel EC, Becker DP (1994) Metabolic changes following cortical contusion: relationships to edema and morphologic changes. Acta Neurochiur (Wien) [Suppl] 60: 446–448
Vespa PM, Nuwer MR, Nenov V, Ronne-Engström E, Hovda DA, Bergsneider M, Kelly DF, Martin NA, Becker DP (1999) Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring. J Neurosurg 91: 750–760
West M, Parkinson D, Havlicek V (1982) Spectral analysis of the electroencephalographic response to experimental concussion in the rat. Electroenceph Clin Neurophysiol 53: 192–200
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Stover, J.F., Sakowitz, O.W., Unterberg, A.W. (2004). Neuronal activity and cortical perfusion determined by quantitative EEG analysis and laser Doppler flowmetry are uncoupled in brain injured rats. In: Baethmann, A., Eriskat, J., Lehmberg, J., Plesnila, N. (eds) Mechanisms of Secondary Brain Damage from Trauma and Ischemia. Acta Neurochirurgica Supplements, vol 89. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0603-7_11
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DOI: https://doi.org/10.1007/978-3-7091-0603-7_11
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-7206-3
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