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Article
Phosphatidylcholine hydroperoxide levels in human plasma are lower than previously reported
The quantification of PC hydroperoxide (PCOOH) in human plasma was studied by HPLC with chemiluminescence detection (HPLC-CL). We identified for the first time the monohydroperoxide of 1-palmitoyl-2-linoleoyl-...
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Article
Consecutive administration of paraquat to rats induces enhanced cholesterol peroxidation and lung injury
It is our hypothesis that as a consequence of increased oxidative stress, rats develop lung injury with increased cholesterol-derived hydroperoxides and oxysterols in lung after consecutive exposure of the rat...
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Article
The importance of alcohol-induced muscle disease
Alcohol-induced muscle disease (AIMD) is a composite term to describe any muscle pathology (molecular, biochemical, structural or physiological) resulting from either acute or chronic alcohol ingestion or a co...
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Article
Paraquat-induced gene expression in rat lung tissues using a differential display reverse transcription-polymerase chain reaction
Increased formation of reactive oxygen species is a cause of paraquat (PQ)-induced injury and also provides a link between the signaling pathways and transcriptional events that regulate the expression of a l...
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Article
Acute effect of ethanol on 7-hydroperoxycholesterol in muscle and liver
We tested the hypotheses that ethanol sensitivities of muscle and liver can be discerned in the initial periods of ethanol exposure, especially when acetaldehyde levels are markedly raised with cyanamide, an a...
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Article
Cholesterol-derived hydroperoxides in alcoholic liver disease
Human liver samples from 33 patients were collected at autopsy (controls’ n=9; fatty liver’ n=12; liver cirrhosis’ n=12)’ and samples homogenized. Lipids extracted with chloroform and methanol were injected into ...
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Article
Chemiluminescent determination of cholesterol hydroperoxides in human erythrocyte membrane
A method for separating, detecting, and quantifying cholesterol hydroperoxide (Ch-OOH) based on extraction, purification by solid-phase extraction cartridge, high-performance liquid chromatography with chemilu...
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Article
Epicoprostanol found in adipocere from five human autopsies
Adipocere formation is well known as a later postmortem change. We collected adipocere from five male victims which had been submerged under the sea or fresh water for 1 mon to 4 yr. Fresh subcutaneous fat of ...
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Article
Chromosomal location and reorganization of the 45S and 5S rDNA in theBrachyscome lineariloba complex (Asteraceae)
The chromosomal locations of the 45S (18S-5.8S-26S) and 5S ribosomal DNA in theBrachyscome lineariloba complex and two related species have been determined by the use of multicolor fluorescencein situ hybridizati...
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Article
Oxysterols found in opacified cornea of fish
We describe a new concept implicating oxidized cholesterol derivatives and very long-chain fatty acids as possible factors in the development of corneal opacification after death. Corneal tissues, removed from...
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Article
Accumulation of 3-(phenylamino)alanine, a constituent in l-tryptophan products implicated in eosinophilia-myalgia syndrome, in blood and organs of the Lewis rats
3-(Phenylamino)alanine (PAA), a newly discovered impurity in case-associated l-tryptophan tablets, has been investigated as a possible contributing factor in the etiology of eosinophilia-myalgia syndrome (EMS). W...
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Chapter and Conference Paper
Phylogenetic relationships of some genera in the Ranunculaceae based on alcohol dehydrogenase genes
Fragments of the nuclear-encoded gene for alcohol dehydrogenase (adh) were amplified from 23 species representing 17 genera in the Ranunculaceae and one in the Berberidaceae using polymerase chain reaction method...
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Article
Identification of four metabolites of 3-(phenylamino)alanine, a constituent in l-tryptophan products implicated in eosinophiliamyalgia syndrome, in rats
3-(Phenylamino)alanine (PAA), a contaminant found in l-tryptophan tablets, has been discussed as a possible cause of eosinophilia-myalgia syndrome (EMS). We administered PAA (100 mg/kg) by gastric gavage to Wista...
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Article
Accumulation of 1-methyl-tetrahydro-Β-carboline-3-carboxylic acid in blood and organs of rat. A possible causative substance of eosinophilia-myalgia syndrome associated with ingestion ofl-tryptophan
1-Methyl-tetrahydro-Β-carboline-3-carboxylic acid (MTCA) may cause eosinophilia-myalgia syndrome (EMS) associated with ingestion ofl-tryptophan. The distribution and excretion of MTCA were studied in rats which h...
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Article
Metabolism and distribution in the rat of peak E substance, a constituent inl-tryptophan product implicated in eosinophilia-myalgia syndrome
Peak E substance, 1,1′-ethylidenebis[tryptophan], a contaminant found inl-tryptophan tablets, has been suggested as a causative agent for eosinophilia-myalgia syndrome (EMS). Peak E substance (50 mg/kg) was admin...
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Article
Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion ofl-tryptophan
1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA) is now thought to be a possible causative substance of eosinophilia-myalgia syndrome associated with ingestion ofl-tryptophan. In the present study...
