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Article
Open AccessNo evidence tube entrapment distresses rodents in typical empathy tests
In the first two experiments an empty tube open at one end was placed in different locations. Male hamsters, tested one at a time, tended to stay close to the tube or in it. During the first minute of the firs...
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Article
Open AccessA case–control study of the association between the gut microbiota and colorectal cancer: exploring the roles of diet, stress, and race
The gut microbiota is associated with risk for colorectal cancer (CRC), a chronic disease for which racial disparities persist with Black Americans having a higher risk of CRC incidence and mortality compared ...
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Article
Open AccessCorrection: System Action Learning: Reorientating Practice for System Change in Preventive Health
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Article
Open AccessRefugees’ Care Experiences, Self-Reported Health Outcomes and Transition to Mainstream Health Care After One Year at the Refugee Engagement and Community Health (REACH) Clinic
This study reports how refugees experienced care at an integrated clinic during their first year in Canada and how they transitioned to a community physician. A survey was completed by 75 Government Assisted R...
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Article
Open AccessSystem Action Learning: Reorientating Practice for System Change in Preventive Health
It is now widely accepted that many of the problems we face in public health are complex, from chronic disease to COVID-19. To grapple with such complexity, researchers have turned to both complexity science a...
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Article
Open AccessLeukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice
Cancer cachexia is a systemic metabolic syndrome characterized by involuntary weight loss, and muscle and adipose tissue wasting. Mechanisms underlying cachexia remain poorly understood. Leukemia inhibitory fa...
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Article
Pelvic floor disorder assessment of knowledge and symptoms: an educational intervention for Spanish-speaking women (PAKS study)
Educational interventions have been effective in improving postpartum knowledge, performance of pelvic floor exercises, and bowel-specific quality-of-life. Our primary objective was to determine if a video-bas...
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Article
Open AccessORC1 binds to cis-transcribed RNAs for efficient activation of replication origins
Cells must coordinate the activation of thousands of replication origins dispersed throughout their genome. Active transcription is known to favor the formation of mammalian origins, although the role that RNA...
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Article
Lipid and Oxidative Methods to Assess the Stability of “Lacon”
Free fatty acids, peroxide, and thiobarbituric acid reactive substances (TBARS) methods were used to assess the effect of the inclusion of chestnuts in the finishing diet of Celta pig breed on the lipid and ox...
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Article
A Systems Thinking Methodology for Studying Prevention Efforts in Communities
The turn to complexity in public health over the past 20 years has come as practitioners, policy makers and scholars lament the lack of progress in addressing wicked problems such as obesity, chronic disease a...
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Article
Open AccessAuthor Correction: Identification and characterization of Cardiac Glycosides as senolytic compounds
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessIdentification and characterization of Cardiac Glycosides as senolytic compounds
Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions. Here we report the identification of Car...
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Article
Open AccessChromatin conformation regulates the coordination between DNA replication and transcription
Chromatin is the template for the basic processes of replication and transcription, making the maintenance of chromosomal integrity critical for cell viability. To elucidate how dividing cells respond to alter...
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Article
Open AccessDiscovering antimalarials with a differential mode of action
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Article
Multiparametric comparison of mesenchymal stromal cells obtained from trabecular bone by using a novel isolation method with those obtained by iliac crest aspiration from the same subjects
Trabecular bone fragments from femoral heads are sometimes used as bone grafts and have been described as a source of mesenchymal progenitor cells. Nevertheless, mesenchymal stromal cells (MSC) from trabecular...
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Article
A comparative study of free and immobilized soybean and horseradish peroxidases for 4-chlorophenol removal: protective effects of immobilization
Horseradish peroxidase (HRP) and soybean peroxidase (SBP) were covalently immobilized onto aldehyde glass through their amine groups. The activity yield and the protein content for the immobilized SBP were hig...
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Chapter and Conference Paper
Modulatory Role of NK1 Receptors in the Basal Ganglia. Studies in NK1-/- Mice
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Article
The sequence and analysis of duplication-rich human chromosome 16
Human chromosome 16 features one of the highest levels of segmentally duplicated sequence among the human autosomes. We report here the 78,884,754 base pairs of finished chromosome 16 sequence, representing ov...
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Article
The DNA sequence and comparative analysis of human chromosome 5
Chromosome 5 is one of the largest human chromosomes and contains numerous intrachromosomal duplications, yet it has one of the lowest gene densities. This is partially explained by numerous gene-poor regions ...
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Article
Quality assessment of the human genome sequence
As the final sequencing of the human genome has now been completed, we present the results of the largest examination of the quality of the finished DNA sequence. The completed study covers the major contribut...
