25 Result(s)
within
John C. Reed
Cancer Research
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Article
Open AccessHIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2
HIV-1 protease (PR) is essential for viral infectivity as it cleaves Gag and Gag-Pol polyprotein precursors during viral maturation. Recent evidence suggests that cellular proteins can also be cleaved by PR, p...
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Chapter
Roles of Apoptosis-Regulating Bcl-2 Family Genes in AML
Among the cardinal features of malignancy is abrogation of cell death mechanisms, thus endowing cancer and leukemia cells with a selective survival advantage relative to normal cells. Genetic and epigenetic le...
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Article
Systematic analysis and validation of differential gene expression in ovarian serous adenocarcinomas and normal ovary
Cancer of the ovary confers the worst prognosis among women with gynecological malignancies, primarily because most ovarian cancers are diagnosed at late stage. Hence, there is a substantial need to develop ne...
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Article
The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex
Shh acts as a survival factor and in its absence its receptor, Patched, induces cell death by recruiting a caspase-activating complex formed by the adaptor protein DRAL, the CARD domain containing proteins TUC...
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Article
Salmonella typhimurium engineered to produce CCL21 inhibit tumor growth
Intravenously-applied bacteria tend to accumulate in tumors and can sporadically lead to tumor regression. Systemic administration of attenuated Salmonella typhimurium is safe and has shown no significant adverse...
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Article
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Perturbations of the endoplasmic reticulum (ER) caused by accumulation of unfolded proteins in this organelle trigger signal-transduction responses that assist...
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Article
BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis
The HIPPI (HIP-1 protein interactor) protein is a multifunctional protein that is involved in the regulation of apoptosis. The interaction partners of HIPPI include HIP-1 (Huntingtin-interacting protein-1), Ap...
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Article
Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate
To characterize the stability, pharmacokinetics and metabolism of analogs of gossypol, apogossypol and apogossypol hexaacetate to provide a basis for comparison.
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Article
Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis
Integrity of the blood vessel wall is essential for vascular homeostasis and organ function1,2. A dynamic balance between endothelial cell survival and apoptosis contributes to this integrity during vascular deve...
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Protocol
Yeast and Mammalian Two-Hybrid Systems for Studying Protein-Protein Interactions
An important step in the analysis of protein function is identification of the interaction partners of each protein. The two-hybrid system has been widely used to identify and explore protein-protein interacti...
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Article
Yeast and apoptosis
Even though yeast lack much of the molecular machinery that is responsible for apoptosis in metazoans, they can be a powerful tool in apoptosis research. The ectopic expression of several animal apoptosis prot...
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Article
Apoptosis and cancer: When BAX is TRAILing away
The development of anticancer therapies that target apoptosis pathways may be hampered by resistance of certain tumor cells to death signals. New findings show that tumor cells lacking the pro-apoptotic protei...
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Article
Apoptosis-based therapies
Physiological cell death, or apoptosis, has an important role in several normal processes, ranging from fetal development to ageing, and defects in the physiol...
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Article
Molecular chaperone targeting and regulation by BAG family proteins
Regulated changes in protein conformation can have profound effects on protein function, although routine laboratory methods often fail to detect them. The recently discovered BAG-family proteins may operate a...
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Article
Response
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Article
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy
The time at which ovarian failure (menopause) occurs in females is determined by the size of the oocyte reserve provided at birth, as well as by the rate at which this endowment is depleted throughout post-nat...
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Article
Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis
Mitochondria trigger apoptosis by releasing caspase activators, including cytochrome c (cytC). Here we show, using a pH-sensitive green fluorescent protein (GFP), that mitochondria-dependent apoptotic stimuli (su...
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Article
Mitochondrial control of cell death
In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise. This has important consequences for the pathophysiology of cell death, as well as fo...
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Article
Survivin’ cell-separation anxiety
Survivin, a cell-death inhibitor, localizes to the spindles of mitotic cells, and its absence causes both a failure in cell division and induction of cell death. Might survivin link the control of cell death w...
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Article
Bcl-2 Gene Family and Related Proteins in Mammary Gland Involution and Breast Cancer
The Bcl-2 gene family regulates tissuedevelopment and tissue homeostasis through the interplayof survival and death factors. Family members arecharacterized as either pro-apoptotic or anti-apoptotic, depending...
