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  1. Article

    Open Access

    Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex

    The DNA-dependent protein kinase (DNA-PK) complex comprises a catalytic (PRKDC) and two requisite DNA-binding (Ku70/Ku80) subunits. The role of the complex in repairing double-stranded DNA breaks (DSBs) is est...

    Mohamed A. Ghonim, Jihang Ju, Kusma Pyakurel, Salome V. Ibba… in Journal of Inflammation (2024)

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    Protocol

    Cell-Penetrating Penta-Peptides and Bax-Inhibiting Peptides: Protocol for Their Application

    The first series of cell-penetrating penta-peptides (CPP5s) were discovered as cytoprotective penta-peptides designed from the Bax-inhibiting domain of Ku70. Bax is an inducer of programmed cell death, and Ku7...

    Jose Gomez, Shigemi Matsuyama in Cell-Penetrating Peptides (2011)

  3. Article

    Correction: Corrigendum: Ku70 suppresses the apoptotic translocation of Bax to mitochondria

    Authors' statement In Fig. 4c–e, Fig. 6e and Supplementary Information, Fig. S2a, western blot images were inappropriately processed for publication by the first author, M. Sawada. Figures containing the corre...

    Motoshi Sawada, Shigemi Matsuyama in Nature Cell Biology (2004)

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    Article

    Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70

    Bax is a pro-apoptotic member of Bcl-2 family proteins and is central to mitochondria-dependent apoptosis1,2,3. Bax resides in the cytosol as a quiescent protein and translocates into mitochondria after apoptotic...

    Motoshi Sawada, Paulette Hayes, Shigemi Matsuyama in Nature Cell Biology (2003)

  5. No Access

    Article

    Ku70 suppresses the apoptotic translocation of Bax to mitochondria

    Bax induces mitochondrial-dependent cell death signals in mammalian cells. However, the mechanism of how Bax is kept inactive has remained unclear. Yeast-based functional screening of Bax inhibitors from mamma...

    Motoshi Sawada, Weiyong Sun, Paulette Hayes, Konstantin Leskov… in Nature Cell Biology (2003)

  6. No Access

    Article

    Response

    John C. Reed, Shigemi Matsuyama, Quinn L. Deveraux, Juan Llopis… in Nature Cell Biology (2000)

  7. No Access

    Article

    Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

    Mitochondria trigger apoptosis by releasing caspase activators, including cytochrome c (cytC). Here we show, using a pH-sensitive green fluorescent protein (GFP), that mitochondria-dependent apoptotic stimuli (su...

    Shigemi Matsuyama, Juan Llopis, Quinn L. Deveraux, Roger Y. Tsien… in Nature Cell Biology (2000)