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Article
Is Violent Video Game Playing Related to Trait Aggression or Depression Among Law Enforcement Officers
Violence remains a contemporary concern in the USA. After high-profile acts of violence are committed, society searches for explanations. This is reflected in concerns regarding unwarranted violence including ...
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Article
Bcl-2 on the brink of breakthroughs in cancer treatment
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Article
Open AccessUbc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity
Obesity is associated with low-grade inflammation that leads to insulin resistance and type 2 diabetes via Toll-like Receptor (TLR) and TNF-family cytokine receptor (TNFR) signaling pathways. Ubc13 is an ubiqu...
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Article
Open AccessHIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2
HIV-1 protease (PR) is essential for viral infectivity as it cleaves Gag and Gag-Pol polyprotein precursors during viral maturation. Recent evidence suggests that cellular proteins can also be cleaved by PR, p...
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Article
Open AccessA REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity
Macroautophagy (autophagy) is a critical cellular stress response; however, the signal transduction pathways controlling autophagy induction in response to stress are poorly understood. Here we reveal a new me...
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Chapter
Roles of Apoptosis-Regulating Bcl-2 Family Genes in AML
Among the cardinal features of malignancy is abrogation of cell death mechanisms, thus endowing cancer and leukemia cells with a selective survival advantage relative to normal cells. Genetic and epigenetic le...
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Article
The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses
Much is known about the activation of inflammasomes, but less is known about their negative regulation. Stehlik and colleagues demonstrate that the pyrin domain–only protein POP3 negatively regulates inflammas...
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Article
Systematic analysis and validation of differential gene expression in ovarian serous adenocarcinomas and normal ovary
Cancer of the ovary confers the worst prognosis among women with gynecological malignancies, primarily because most ovarian cancers are diagnosed at late stage. Hence, there is a substantial need to develop ne...
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Protocol
Reconstituting the NLRP1 Inflammasome In Vitro
Nucleotide-binding domain leucine-rich-repeat containing receptors; NOD-Like Receptors (NLRs) were originally described as microbial sensors involved in host defense against pathogens that comprise an importan...
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Article
Correction: Corrigendum: Yeretssian et al. reply
Nature 488, E6–E8 (2012); doi:10.1038/nature11367 In our Reply to the Brief Communications Arising ‘Is BID required for NOD signalling?’ we made use of a figure generated by the authors of the Comment (Nature ...
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Yeretssian et al. reply
Replying to U. Nachbur, J. E. Vince, L. A. O'Reilly, A. Strasser & J. Silke Nature 488, 10.1038/nature11366 (2012).
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Article
Proteomic profiling of differentially expressed proteins from Bax inhibitor-1 knockout and wild type mice
Bax inhibitor-1 (BI-1) is an anti-apoptotic protein located in the endoplasmic reticulum (ER). The role of BI-1 has been studied in different physiopathological models including ischemia, diabetes, liver regen...
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Article
The NIH's role in accelerating translational sciences
The NIH's proposed initiatives in translational science deserve solid financial backing from legislators and vocal support from the biomedical community.
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Article
Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples
The B-cell lymphoma-2 (Bcl-2) family contains six antiapoptotic members, each with a hydrophobic pocket in which Bcl-2 homology region 3 (BH3) helices bind. This binding quenches apoptotic signals from activat...
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NIH: translation centre bridges a gap
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Article
Non-apoptotic role of BID in inflammation and innate immunity
The proapoptotic BCL2 family protein BID has been found to modulate inflammation and innate immunity in intestinal epithelial cells, independently of its role in apoptosis. BID acts through NOD1 and NOD2, the ...
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Article
Immunoexpression of Survivin in non-neoplastic lymphoid tissues and malignant lymphomas using a new monoclonal antibody reactive on paraffin sections
Survivin is a member of the inhibitor of apoptosis gene family, which is also implicated in mitosis regulation. Most reports in the literature impute poor prognosis to neoplasms with overexpression of this pro...
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Article
The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex
Shh acts as a survival factor and in its absence its receptor, Patched, induces cell death by recruiting a caspase-activating complex formed by the adaptor protein DRAL, the CARD domain containing proteins TUC...
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Article
Salmonella typhimurium engineered to produce CCL21 inhibit tumor growth
Intravenously-applied bacteria tend to accumulate in tumors and can sporadically lead to tumor regression. Systemic administration of attenuated Salmonella typhimurium is safe and has shown no significant adverse...
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Article
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Perturbations of the endoplasmic reticulum (ER) caused by accumulation of unfolded proteins in this organelle trigger signal-transduction responses that assist...
