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Article
Open AccessAutomatic classification of normal and abnormal cell division using deep learning
In recent years, there has been a surge in the development of methods for cell segmentation and tracking, with initiatives like the Cell Tracking Challenge driving progress in the field. Most studies focus on ...
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Article
SIRPα-specific monoclonal antibody enables antibody-dependent phagocytosis of neuroblastoma cells
Immunotherapy with anti-GD2 monoclonal antibodies (mAbs) provides some benefits for patients with neuroblastoma (NB). However, the therapeutic efficacy remains limited, and treatment is associated with significan...
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Article
Open AccessWild-type isocitrate dehydrogenase under the spotlight in glioblastoma
Brain tumors actively reprogram their cellular metabolism to survive and proliferate, thus offering potential therapeutic opportunities. Over the past decade, extensive research has been done on mutant IDH enzyme...
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Article
Open AccessGlutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model
Glioblastoma (GBM) are highly heterogeneous on the cellular and molecular basis. It has been proposed that glutamine metabolism of primary cells established from human tumors discriminates aggressive mesenchym...
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Article
Open AccessCaveolin-1 regulates the ASMase/ceramide-mediated radiation response of endothelial cells in the context of tumor–stroma interactions
The integral membrane protein caveolin-1 (CAV1) plays a central role in radioresistance-mediating tumor–stroma interactions of advanced prostate cancer (PCa). Among the tumor–stroma, endothelial cells (EC) evo...
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Scalable Interactive Platform for Geographic Evaluation of Sea-Level Rise Impact Combining High-Performance Computing and WebGIS Client
is changing, more applied information on resulting impacts are required to inform adaptation . Over the last decade, the amount of information relevant to climate change impact has grown drastically....
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Open AccessOptimizing radiotherapy protocols using computer automata to model tumour cell death as a function of oxygen diffusion processes
The concept of hypofractionation is gaining momentum in radiation oncology centres, enabled by recent advances in radiotherapy apparatus. The gain of efficacy of this innovative treatment must be defined. We p...
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Open AccessStereotactic body radiation therapy for abdominal oligometastases: a biological and clinical review
Advances in imaging and biological targeting have led to the development of stereotactic body radiation therapy (SBRT) as an alternative treatment of extracranial oligometastases. New radiobiological concepts,...
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Article
ATM regulates target switching to escalating doses of radiation in the intestines
Although stem cells succumbing to reproductive death are assumed to be the single relevant targets in radiation tissue damage, recent studies showed intestinal stem cell damage is conditionally linked to crypt...
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Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring
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Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy
The time at which ovarian failure (menopause) occurs in females is determined by the size of the oocyte reserve provided at birth, as well as by the rate at which this endowment is depleted throughout post-nat...
