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Open AccessCancer metastasis chemoprevention prevents circulating tumour cells from germination
The war against cancer traces back to the signature event half-a-century ago when the US National Cancer Act was signed into law. The cancer crusade costs trillions with disappointing returns, teasing the poss...
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Open AccessCorrection to: Embedding similarities between embryos and circulating tumor cells: fundamentals of abortifacients used for cancer metastasis chemoprevention
An amendment to this paper has been published and can be accessed via the original article.
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Open AccessNOL7 facilitates melanoma progression and metastasis
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Open AccessEmbedding similarities between embryos and circulating tumor cells: fundamentals of abortifacients used for cancer metastasis chemoprevention
The global epidemiological studies reported lower cancer risk after long-term use of contraceptives. Our systematic studies demonstrated that abortifacients are effective in preventing cancer metastases induce...
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Open AccessAuthor Correction: Achyranthes bidentata polysaccharide can safely prevent NSCLC metastasis via targeting EGFR and EMT
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessAchyranthes bidentata polysaccharide can safely prevent NSCLC metastasis via targeting EGFR and EMT
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WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5–MDM2–p53 pathway
The key molecules and underlying mechanisms of melanoma metastasis remain poorly understood. Using isobaric tag for relative and absolute quantitation (iTRAQ) proteomic screening, probing of patients’ samples,...
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Open AccessPublisher Correction: Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessEliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
There are disease-causing biohazards in the blood that cannot be treated with modern medicines. Here we show that an intelligently designed safe biomaterial can precisely identify, tow and dump a targeted bioh...
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Open AccessRedox/NIR dual-responsive MoS2 for synergetic chemo-photothermal therapy of cancer
The construction of a multifunctional drug delivery system with a variety of advantageous features, including targeted delivery, controlled release and combined therapy, is highly attractive but remains a chal...
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Open AccessFunctionalized MoS2-erlotinib produces hyperthermia under NIR
Molybdenum disulfide (MoS2) has been widely explored for biomedical applications due to its brilliant photothermal conversion ability. In this paper, we report a novel multifunctional MoS2-based drug delivery sys...
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Open AccessCo-delivery of sorafenib and metapristone encapsulated by CXCR4-targeted PLGA-PEG nanoparticles overcomes hepatocellular carcinoma resistance to sorafenib
Sorafenib is approved as a standard therapy for advanced hepatocellular carcinoma (HCC), but its clinical application is limited due to moderate therapeutic efficacy and high incidence of acquired resistance r...
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Open AccessDual blockage of both PD-L1 and CD47 enhances immunotherapy against circulating tumor cells
Carcinoma metastasis is triggered by a subpopulation of circulating tumor cells (CTCs). And single immune checkpoint therapy is not good enough to inhibit CTC-induced metastasis. Here, we demonstrate that simu...
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Open AccessSex-related pharmacokinetic differences and mechanisms of metapristone (RU486 metabolite)
Metapristone is the primary metabolite of the abortifacient mifepristone (RU486), and is being developed as a safe and effective cancer metastatic chemopreventive agent for both sexes. Here, we systematically ...
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A Flavonoid Glycoside Compound from Murraya paniculata (L.) Interrupts Metastatic Characteristics of A549 Cells by Regulating STAT3/NF-κB/COX-2 and EGFR Signaling Pathways
Metastasis remains the leading cause of death from lung carcinoma. It is urgent to find safe and efficient pre-metastasis preventive agents for cancer survivors. We isolated a flavonoid glycoside, hexamethoxy ...
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Open AccessGlobal deregulation of ginseng products may be a safety hazard to warfarin takers: solid evidence of ginseng-warfarin interaction
Recent global deregulation of ginseng as the table food raises our concern about the possible ginseng-warfarin interaction that could be life-threatening to patients who take warfarin for preventing fatal stro...
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Open AccessThe traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology
Our recent biosystems analysis revealed similarities between embryonic implantation and cancer cell adhesion, which suggests that abortifacients may be good for safe and effective metastatic chemoprevention ta...
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Aptamer-Conjugated Chitosan-Anchored Liposomal Complexes for Targeted Delivery of Erlotinib to EGFR-Mutated Lung Cancer Cells
Lung cancer is the leading cancer and has the highest death rate. The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) erlotinib has had a promising response in lung cancer therapy. Unfo...
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Open AccessWarfarin and coumarin-like Murraya paniculata extract down-regulate EpCAM-mediated cell adhesion: individual components versus mixture for studying botanical metastatic chemopreventives
We recently defined cancer metastatic chemoprevention as utilizing safe and effective molecules to comprehensively prevent the spark of activation-adhesion-extravasation-proliferation metastatic cascade caused...
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Open AccessPharmacoproteomic analysis reveals that metapristone (RU486 metabolite) intervenes E-cadherin and vimentin to realize cancer metastasis chemoprevention
Metapristone is the most predominant biological active metabolite of mifepristone and being developed as a novel cancer metastasis chemopreventive agent by us. Despite its prominent metastasis chemopreventive ...
