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Article
Open AccessIdentification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer
Since metastatic colorectal cancer (CRC) is a leading cause of cancer-related death, therapeutic approaches overcoming primary and acquired therapy resistance are an urgent medical need. In this study, the eff...
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Article
Open AccessBcl-xL is an oncogenic driver in colorectal cancer
Colorectal cancer (CRC) is the second most common malignant neoplasia in women and men worldwide. The B-cell lymphoma 2 (Bcl-2) protein family is mainly known for its pivotal role in the regulation of the mito...
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Article
Open AccessThe HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration
The high-mobility group box 1 (HMGB1) protein has a central role in immunological antitumour defense. Here we show that natural killer cell-derived HMGB1 directly eliminates cancer cells by triggering metaboli...
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Article
Neue Aspekte der Regulation von Zelltod in Tumoren
Störungen in der Regulation des Zelltodes sind wichtige Ursachen für die Entstehung von Krebs. Das HMGB1-Protein löst eine bislang nicht beschriebene Art des Zelltodes aus, die zukünftig auch zur Therapie mali...
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Article
Sudden death of an immunocompetent young adult caused by novel (swine origin) influenza A/H1N1-associated myocarditis
The main cause of death from novel (swine origin) influenza A/H1N1 infection is acute respiratory distress syndrome. Most fatal cases are immunocompromised patients or patients with a severe underlying disease...
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Article
BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis
The HIPPI (HIP-1 protein interactor) protein is a multifunctional protein that is involved in the regulation of apoptosis. The interaction partners of HIPPI include HIP-1 (Huntingtin-interacting protein-1), Ap...
