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Article
Open AccessSarcopenia in idiopathic pulmonary fibrosis: a prospective study exploring prevalence, associated factors and diagnostic approach
Sarcopenia gained importance in the evaluation of patients with chronic respiratory diseases, including idiopathic pulmonary fibrosis (IPF), since it may impact negatively on clinical outcomes.
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Article
Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys
Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Her...
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Article
Open AccessResponse to BNT162b2 mRNA COVID-19 vaccine among healthcare workers in Italy: a 3-month follow-up
This study investigated the response to BNT162b2 mRNA COVID-19 vaccine among healthcare workers (HCWs) in an Italian teaching hospital. 444 participants were surveyed with either multiple RT-PCR assays for det...
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Article
Open AccessPost-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis
Abnormal kidney development leads to lower nephron number, predisposing to renal diseases in adulthood. In embryonic kidneys, nephron endowment is dictated by the availability of nephron progenitors, whose sel...
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Article
The natural history of idiopathic pulmonary fibrosis in a large European population: the role of age, sex and comorbidities
Placebo arms of clinical trials provide an opportunity to investigate the natural history of idiopathic pulmonary fibrosis (IPF) but these patients are not representative of the real life IPF population. Objec...
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Article
Open AccessElectron–hole superfluidity in strained Si/Ge type II heterojunctions
Excitons are promising candidates for generating superfluidity and Bose–Einstein condensation (BEC) in solid-state devices, but an enabling material platform with in-built band structure advantages and scaling...
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Article
Open AccessRecruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord
Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, lo...
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Article
Open AccessEngineering the vasculature of decellularized rat kidney scaffolds using human induced pluripotent stem cell-derived endothelial cells
Generating new kidneys using tissue engineering technologies is an innovative strategy for overcoming the shortage of donor organs for transplantation. Here we report how to efficiently engineer the kidney vas...
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Article
Open AccessPressure support ventilation + sigh in acute hypoxemic respiratory failure patients: study protocol for a pilot randomized controlled trial, the PROTECTION trial
Adding cyclic short sustained inflations (sigh) to assisted ventilation yields optimizes lung recruitment, decreases heterogeneity and reduces inspiratory effort in patients with acute hypoxemic respiratory fa...
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Article
Open AccessEarly and late scanning electron microscopy findings in diabetic kidney disease
Diabetic nephropathy (DN), the single strongest predictor of mortality in patients with type 2 diabetes, is characterized by initial glomerular hyperfiltration with subsequent progressive renal function loss w...
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Open AccessHuman mesenchymal stromal cells transplanted into mice stimulate renal tubular cells and enhance mitochondrial function
Mesenchymal stromal cells (MSCs) are renoprotective and drive regeneration following injury, although cellular targets of such an effect are still ill-defined. Here, we show that human umbilical cord (UC)-MSCs...
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Article
Open AccessExtracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival
We have previously shown that rat allogeneic DC, made immature by adenoviral gene transfer of the dominant negative form of IKK2, gave rise in-vitro to a unique population of CD4+CD25− regulatory T cells (dnIKK2-...
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Article
Podocyte–actin dynamics in health and disease
The actin cytoskeleton of podocytes reflects their physiological functions and underlies their unique morphology, which can adjust in response to environmental...
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Article
Angiotensin receptors as determinants of life span
Angiotensin II (Ang II), the central product of renin-angiotensin system, has a role in the etiology of hypertension and in pathophysiology of cardiac and renal diseases in humans. Other functions of Ang II in...
