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Article
Open AccessEngineering the vasculature of decellularized rat kidney scaffolds using human induced pluripotent stem cell-derived endothelial cells
Generating new kidneys using tissue engineering technologies is an innovative strategy for overcoming the shortage of donor organs for transplantation. Here we report how to efficiently engineer the kidney vas...
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Article
Open AccessRenal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury
Acute kidney injury (AKI) is one of the most relevant health issues, leading to millions of deaths. The magnitude of the phenomenon remarks the urgent need for innovative and effective therapeutic approaches. ...
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Chapter
The Desensitisation as A3 Adenosine Receptor Regulation: Physiopathological Implications
A3 adenosine receptors are subjected to fast desensitisation, internalisation and down regulation after agonist exposure. As almost all G-protein coupled receptors, these regulatory mechanisms are mediated by re....
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Article
Open AccessThe obesity and inflammatory marker haptoglobin attracts monocytes via interaction with chemokine (C-C motif) receptor 2 (CCR2)
Obesity is a chronic low inflammatory state. In the obesity condition the white adipose tissue (WAT) is massively infiltrated with monocytes/macrophages, and the nature of the signals recruiting these inflamma...
