-
Chapter
Digital Bridge to Restore Voluntary Control of Leg Movements After Paralysis
Spinal cord injury disrupts the connection between the brain and the regions of the spinal cord located below the lesion. This disruption impairs or even suppresses voluntary control of muscles, leading to per...
-
Article
Open AccessWalking naturally after spinal cord injury using a brain–spine interface
A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis1,2. Here, we restored this communication with a digital bridge bet...
-
Article
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads tha...
-
Article
Open AccessRecruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord
Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, lo...
-
Article
Behavioural responses to a photovoltaic subretinal prosthesis implanted in non-human primates
Retinal dystrophies and age-related macular degeneration related to photoreceptor degeneration can cause blindness. In blind patients, although the electrical activation of the residual retinal circuit can pro...
-
Article
Open AccessTemporal structure in spiking patterns of ganglion cells defines perceptual thresholds in rodents with subretinal prosthesis
Subretinal prostheses are designed to restore sight in patients blinded by retinal degeneration using electrical stimulation of the inner retinal neurons. To relate retinal output to perception, we studied beh...
-
Chapter
High Resolution Photovoltaic Subretinal Prosthesis for Restoration of Sight
In photovoltaic subretinal prostheses, each pixel converts light into electric current to stimulate the nearby inner retinal neurons. Visual information is projected onto the implant by video goggles using pul...
-
Article
Photovoltaic restoration of sight with high visual acuity
A photovoltaic retinal prosthesis activated by light restores half of normal visual acuity in rats blinded by retinal degeneration.
-
Chapter and Conference Paper
Taurine Is a Crucial Factor to Preserve Retinal Ganglion Cell Survival
Retinal ganglion cells (RGCs) are spiking neurons, which send visual information to the brain, through the optic nerve. RGC degeneration occurs in retinal diseases, either as a primary process or secondary to ...
