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Article
Open AccessDe novo motor learning creates structure in neural activity that shapes adaptation
Animals can quickly adapt learned movements to external perturbations, and their existing motor repertoire likely influences their ease of adaptation. Long-term learning causes lasting changes in neural connec...
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Article
A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease
People with late-stage Parkinson’s disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesi...
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Article
Open AccessPreserved neural dynamics across animals performing similar behaviour
Animals of the same species exhibit similar behaviours that are advantageously adapted to their body and environment. These behaviours are shaped at the species level by selection pressures over evolutionary t...
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Article
Open AccessSmall, correlated changes in synaptic connectivity may facilitate rapid motor learning
Animals rapidly adapt their movements to external perturbations, a process paralleled by changes in neural activity in the motor cortex. Experimental studies suggest that these changes originate from altered i...
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Article
Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys
Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Her...
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Article
Long-term stability of cortical population dynamics underlying consistent behavior
Animals readily execute learned behaviors in a consistent manner over long periods of time, and yet no equally stable neural correlate has been demonstrated. How does the cortex achieve this stable control? Us...
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Article
Linear-nonlinear-time-warp-poisson models of neural activity
Prominent models of spike trains assume only one source of variability – stochastic (Poisson) spiking – when stimuli and behavior are fixed. However, spike trains may also reflect variability due to internal p...
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Article
Open AccessCortical population activity within a preserved neural manifold underlies multiple motor behaviors
Populations of cortical neurons flexibly perform different functions; for the primary motor cortex (M1) this means a rich repertoire of motor behaviors. We investigate the flexibility of M1 movement control by...
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Article
Open AccessPopulation coding of conditional probability distributions in dorsal premotor cortex
Our bodies and the environment constrain our movements. For example, when our arm is fully outstretched, we cannot extend it further. More generally, the distribution of possible movements is conditioned on th...
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Article
A cryptography-based approach for movement decoding
Brain decoders use neural recordings to infer the activity or intent of a user. To train a decoder, one generally needs to infer the measured variables of interest (covariates) from simultaneously measured neu...
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Article
Altered tuning in primary motor cortex does not account for behavioral adaptation during force field learning
Although primary motor cortex (M1) is intimately involved in the dynamics of limb movement, its inputs may be more closely related to higher-order aspects of movement and multi-modal sensory feedback. Motor le...
