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Article
Sirtuins in kidney health and disease
Sirtuins (SIRTs) are putative regulators of lifespan in model organisms. Since the initial discovery that SIRTs could promote longevity in nematodes and flies, the identification of additional properties of th...
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Article
Open AccessSARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling
The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can interact with endothelial cells. However, no studies demonstrated the direct effect of the spike protein subunit 1 (S1) in ...
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Article
Open AccessPost-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis
Abnormal kidney development leads to lower nephron number, predisposing to renal diseases in adulthood. In embryonic kidneys, nephron endowment is dictated by the availability of nephron progenitors, whose sel...
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Article
Immunity, endothelial injury and complement-induced coagulopathy in COVID-19
In December 2019, a novel coronavirus was isolated from the respiratory epithelium of patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute respiratory syndrome coronavirus 2 (...
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Article
Open AccessManipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes
More effective treatments for diabetic nephropathy remain a major unmet clinical need. Increased oxidative stress is one of the most important pathological mechanisms that lead to kidney damage and functional ...
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Article
Open AccessHuman mesenchymal stromal cells transplanted into mice stimulate renal tubular cells and enhance mitochondrial function
Mesenchymal stromal cells (MSCs) are renoprotective and drive regeneration following injury, although cellular targets of such an effect are still ill-defined. Here, we show that human umbilical cord (UC)-MSCs...
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Article
Podocyte–actin dynamics in health and disease
The actin cytoskeleton of podocytes reflects their physiological functions and underlies their unique morphology, which can adjust in response to environmental...
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Article
Open AccessA previously unrecognized role of C3a in proteinuric progressive nephropathy
Podocyte loss is the initial event in the development of glomerulosclerosis, the structural hallmark of progressive proteinuric nephropathies. Understanding mechanisms underlying glomerular injury is the key c...
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Chapter and Conference Paper
Self-Organisation and Cortical Dynamics
Starting from the problem of density estimation, in a previous paper [1] we have shown how EM learning can be considered as a Hebbian mechanism. From this it is possible to outline a theory of self-organisatio...
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Chapter and Conference Paper
Extending the TRN model in a biologically plausible way
The Topology Representing Network (TRN) model is extended by using an activation dynamics which implicitly orders the neurons according to the distance from the input pattern. This allows to apply the same Hebbia...
