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Article
Open AccessPerfusion deficits may underlie lung and kidney injury in severe COVID-19 disease: insights from a multicenter international cohort study
Lung perfusion defects, mainly due to endothelial and coagulation activation, are a key contributor to COVID-19 respiratory failure. COVID-19 patients may also develop acute kidney injury (AKI) because of rena...
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Article
Open AccessA non-invasive continuous and real-time volumetric monitoring in spontaneous breathing subjects based on bioimpedance—ExSpiron®**: a validation study in healthy volunteers
Tidal volume (TV) monitoring breath-by-breath is not available at bedside in non-intubated patients. However, TV monitoring may be useful to evaluate the work of breathing. A non-invasive device based on bioim...
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Article
Open AccessPulmonary shunt in critical care: a practical approach with clinical scenarios
Pulmonary shunt refers to the passage of venous blood into the arterial blood system bypassing the alveoli-blood gas exchange. Pulmonary shunt is defined by a drop in the physiologic coupling of lung ventilati...
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Article
Open AccessTwo-year cardio-pulmonary follow-up after severe COVID-19: a prospective study
Short- and medium-term cardio-pulmonary sequelae after COVID-19 have been extensively studied. However, studies with longer follow-ups are required. This study aims to identify and characterise cardio-pulmonar...
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Article
Open AccessOverestimation of driving pressure by the analysis of the conductive pressure during venous-arterial ECMO: Airway Closure or Intrinsic PEEP?
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Article
Open AccessIndividual response in patient’s effort and driving pressure to variations in assistance during pressure support ventilation
During Pressure Support Ventilation (PSV) an inspiratory hold allows to measure plateau pressure (Pplat), driving pressure (∆P), respiratory system compliance (Crs) and pressure-muscle-index (PMI), an index of...
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Article
Open AccessA technique to measure tidal volume during noninvasive respiratory support by continuous-flow helmet CPAP
The coronavirus disease 2019 (COVID-19) pandemic has promoted the use of helmet continuous positive airway pressure (CPAP) for noninvasive respiratory support in hypoxic respiratory failure patients, despite t...
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Article
Open AccessEnhanced perioperative care in emergency general surgery: the WSES position paper
Enhanced perioperative care protocols become the standard of care in elective surgery with a significant improvement in patients’ outcome. The key element of the enhanced perioperative care protocol is the mul...
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Article
Open AccessImplementing Enhanced Perioperative Care in Emergency General Surgery: A Prospective Multicenter Observational Study
ERAS pathway has been proposed as the standard of care in elective abdominal surgery. Guidelines on ERAS in emergency surgery have been recently published; however, few evidences are still available in the lit...
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Article
Open AccessClinical risk factors for increased respiratory drive in intubated hypoxemic patients
There is very limited evidence identifying factors that increase respiratory drive in hypoxemic intubated patients. Most physiological determinants of respiratory drive cannot be directly assessed at the bedsi...
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Article
Multivariate Curve Resolution Applied to Near Infrared Spectroscopic Data Acquired Throughout the Cooking Process to Monitor Evolving Béchamel Sauces
This study presents an exploratory analysis of the kinetics and mechanisms involved in the cooking process of 27 béchamel sauces. The evolving béchamel sauces during their elaboration were investigated using a...
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Article
Role of PEEP on the prognostic performance of the ROX index in hypoxemic respiratory failure due to COVID-19: any further gain in outcome prediction?
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Article
Frailty and long-COVID: is COVID-19 responsible for a transition in frailty status among older adults who survived hospitalization for COVID-19?
There is a paucity of knowledge about the effects of COronaVIrus Disease-19 (COVID-19) on long-term frailty development or progression over time.
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Article
Open AccessOne-year pulmonary impairment after severe COVID-19: a prospective, multicenter follow-up study
Long-term pulmonary sequelae following hospitalization for SARS-CoV-2 pneumonia is largely unclear. The aim of this study was to identify and characterise pulmonary sequelae caused by SARS-CoV-2 pneumonia at 1...
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Article
Open AccessExtracorporeal membrane oxygenation for COVID-19 and influenza H1N1 associated acute respiratory distress syndrome: a multicenter retrospective cohort study
Extracorporeal membrane oxygenation (ECMO) has become an established rescue therapy for severe acute respiratory distress syndrome (ARDS) in several etiologies including influenza A H1N1 pneumonia. The benefit...
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Article
Open AccessIndividualized positive end-expiratory pressure guided by end-expiratory lung volume in early acute respiratory distress syndrome: study protocol for the multicenter, randomized IPERPEEP trial
In acute respiratory distress syndrome (ARDS), response to positive end-expiratory pressure (PEEP) is variable according to different degrees of lung recruitability. The search for a tool to individualize PEEP...
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Article
Open AccessProne positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a pooled individual patient data analysis
Prone positioning (PP) reduces mortality of patients with acute respiratory distress syndrome (ARDS). The potential benefit of prone positioning maneuvers during venovenous extracorporeal membrane oxygenation ...
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Veno-Venous ECMO and ECCO2R
Veno-venous Extracorporeal Membrane Oxygenation (V-V ECMO) allows to provide CO2 removal, oxygenation and lung rest in the most severe ARDS patients, thus minimizing ventilation-induced lung injury (VILI). In the...
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Article
Open AccessThe use of head helmets to deliver noninvasive ventilatory support: a comprehensive review of technical aspects and clinical findings
A helmet, comprising a transparent hood and a soft collar, surrounding the patient’s head can be used to deliver noninvasive ventilatory support, both as continuous positive airway pressure and noninvasive po...
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Article
The heterogeneity of lung perfusion patterns in SPECT/CT during COVID-19: not only embolism