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Article
Diffusion magnetic resonance imaging for kidney cyst volume quantification and non-cystic tissue characterisation in ADPKD
Beyond total kidney and cyst volume (TCV), non-cystic tissue plays an important role in autosomal dominant polycystic kidney disease (ADPKD) progression. This study aims at presenting and preliminarily validat...
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Article
Glomerular hyperfiltration
Circulating blood is filtered across the glomerular barrier to form an ultrafiltrate of plasma in the Bowman’s space. The volume of glomerular filtration adjusted by time is defined as the glomerular filtratio...
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Article
Open AccessIn search of an ideal drug for safer treatment of obesity: The false promise of pseudoephedrine
Obesity is a major public health problem worldwide. Only relatively few treatment options are, at present, available for the management of obese patients. Furthermore, treatment of obesity is affected by the w...
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Chapter
Proteinuria and Tubulotoxicity
Chronic proteinuric renal diseases, independent from the type of the insult, have in common the loss of selectivity of the glomerular barrier to protein filtration. The glomerular ultrafiltration of excessive ...
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Article
Maternal and environmental risk factors for neonatal AKI and its long-term consequences
Acute kidney injury (AKI) is a common and life-threatening complication in critically ill neonates. Gestational risk factors for AKI include premature birth, intrauterine growth restriction and low birthweight...
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Article
Open AccessA comparison of metrics and performance characteristics of different search strategies for article retrieval for a systematic review of the global epidemiology of kidney and urinary diseases
Conducting a systematic review requires a comprehensive bibliographic search. Comparing different search strategies is essential for choosing those that cover all useful data sources. Our aim was to develop se...
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Article
Open AccessEarly and late scanning electron microscopy findings in diabetic kidney disease
Diabetic nephropathy (DN), the single strongest predictor of mortality in patients with type 2 diabetes, is characterized by initial glomerular hyperfiltration with subsequent progressive renal function loss w...
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Article
Prevention programs for chronic kidney disease in low-income countries
Chronic kidney disease (CKD) is an important determinant of the poor health outcome for major noncommunicable diseases that are the leading cause of death worldwide. Early recognition with screening programs o...
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Article
Mesenchymal stromal cells in renal transplantation: opportunities and challenges
The unique immunomodulatory properties of multipotent mesenchymal stromal cells (MSCs) make MSC-based therapy one of the most promising tolerance-promoting cel...
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Article
Drug development: how academia, industry and authorities interact
Drug trial and approval processes are often affected by the conflicting interests of regulatory authorities, academia, and the pharmaceutical industry. In this Perspectives article, Silvio Garattini and Norber...
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Article
Multipotent Mesenchymal Stromal Cell Therapy and Risk of Malignancies
Cell therapy with Multipotent Mesenchymal Stromal Cells (MSC) holds enormous promise for the treatment of a large number of degenerative and immune/inflammatory diseases. Their multilineage differentiation pot...
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Article
Do mTOR inhibitors still have a future in ADPKD?
Two trials recently reported in the New England Journal of Medicine report that use of mammalian target of rapamycin inhibitors does little to halt the progression of autosomal dominant polycystic kidney disease....
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Article
Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection
Chronic kidney disease (CKD) is a worldwide threat to public health, but the scale of the problem is probably not fully appreciated. At present, there are no s...
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Chapter
Prevention of Chronic Renal Diseases in the Elderly
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Article
Mechanisms of Disease: pre-eclampsia
In this comprehensive review, Giuseppe Remuzzi and colleagues present a hypothesis for the pathophysiology of pre-eclampsia that unifies findings from a recent flurry of research. These new insights should spu...
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Chapter
Calcineurin inhibitors and sirolimus
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Article
New therapeutics that antagonize endothelin: promises and frustrations
The vascular endothelium synthesizes and releases a range of vasodilators and vasoconstrictors that have key roles in the local regulation of vascular tone.
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Article
Conflict of interest as seen from a researcher’s perspective
The continuous growth of the pharmaceutical industry is expected to require a considerable output of new drugs, with speedy development and approval processes. This profit-driven expansion of the drug market m...
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Chapter
Molecular Medicine in Organ Transplantation: How and When?
Short-term graft survival has been remarkably improved in the past two decades thanks to increased skill coupled with new immunosuppressants. Although 1 year graft survival is now close to 85–90%, at least for...
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Chapter
Pharmacologic Monitoring of Immunosuppressive Drugs
Organ transplantation as a treatment modality for patients with end-stage organ diseases of kidney, heart, liver, and pancreas has achieved impressive results in the past 2 decades thanks to better understandi...
