15 Result(s)
within
A. C. Heath
Pharmacotherapy
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Article
Open AccessThe genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data
The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as pre...
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Open AccessGenome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned
Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 cases, 3673 screened controls and >1 M imp...
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Open AccessCommon SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion
The personality traits of neuroticism and extraversion are predictive of a number of social and behavioural outcomes and psychiatric disorders. Twin and family studies have reported moderate heritability estim...
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Erratum: Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion
Correction to: Translational Psychiatry (2012) 2, e102; doi:10.1038/tp.2012.27; published online 17 April 2012 Following the online publication of this article, the authors noted that the affiliation for Dr A ...
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Open AccessA genome-wide meta-analysis of association studies of Cloninger's Temperament Scales
Temperament has a strongly heritable component, yet multiple independent genome-wide studies have failed to identify significant genetic associations. We have assembled the largest sample to date of persons wi...
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Open AccessThe genetics of addiction—a translational perspective
Addictions are serious and common psychiatric disorders, and are among the leading contributors to preventable death. This selective review outlines and highlights the need for a multi-method translational app...
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Erratum: The genetics of addiction—a translational perspective
Correction to: Translational Psychiatry (2012) 2, e140; doi:10.1038/tp.2012.54; published online 17 July 2012 As the result of an editing error, two check marks were omitted from Box 1. In the ‘DSM-5’ column, ...
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Open AccessGenome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM
Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N=18 176) and sought replication of our top...
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Open AccessMulti-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder
Major depressive disorder (MDD) is a common psychiatric illness characterized by low mood and loss of interest in pleasurable activities. Despite years of effort, recent genome-wide association studies (GWAS) ...
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Open AccessMonozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin
Our understanding of major depressive disorder (MDD) has focused on the influence of genetic variation and environmental risk factors. Growing evidence suggests the additional role of epigenetic mechanisms inf...
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Open AccessGenome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium
Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psycholog...
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Open AccessGenome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures
Age at onset of alcohol dependence (AO-AD) is a defining feature of multiple drinking typologies. AO-AD is heritable and likely shares genetic liability with other aspects of alcohol consumption. We examine wh...
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Erratum: Meta-analysis of genome-wide association studies of anxiety disorders
Correction to: Molecular Psychiatry (2015); advance online publication 12 January 2016; doi:10.1038/mp.2015.197 Following publication of the above article, the authors noticed that the fifteenth author’s name ...
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Open AccessGenetic effects influencing risk for major depressive disorder in China and Europe
Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity...
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Open AccessA direct test of the diathesis–stress model for depression
The diathesis–stress theory for depression states that the effects of stress on the depression risk are dependent on the diathesis or vulnerability, implying multiplicative interactive effects on the liability...
