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  1. No Access

    Article

    Disruption of the 5S RNP–Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia

    Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-m...

    P Jaako, S Debnath, K Olsson, Y Zhang, J Flygare, M S Lindström, D Bryder… in Leukemia (2015)

  2. No Access

    Article

    TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia

    Members of the TALE (three-amino-acid loop extension) family of atypical homeodomain-containing transcription factors are important downstream effectors of oncogenic fusion proteins involving the mixed lineage...

    A Willer, J S Jakobsen, E Ohlsson, N Rapin, J Waage, M Billing, L Bullinger… in Leukemia (2015)

  3. No Access

    Article

    SPARC is dispensable for murine hematopoiesis, despite its suspected pathophysiological role in 5q-myelodysplastic syndrome

    K Siva, P Jaako, K Miharada, E Rörby, M Ehinger, G Karlsson, S Karlsson in Leukemia (2012)

  4. No Access

    Article

    The role of Smad signaling in hematopoiesis and translational hematology

    Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and function to produce and regenerate the entire blood and immune system over the course of an individual's lifetime. Histor...

    U Blank, S Karlsson in Leukemia (2011)

  5. No Access

    Article

    Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications

    The hematopoietic stem cell (HSC) is the prototype organ-regenerating stem cell (SC), and by far the most studied type of SC in the body. Currently, HSC-based therapy is the only routinely used SC therapy; how...

    F J T Staal, C Baum, C Cowan, E Dzierzak, S Hacein-Bey-Abina, S Karlsson… in Leukemia (2011)

  6. Article

    Open Access

    High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event

    Multiple genetic hits are detected in patients with acute myeloid leukemia (AML). To investigate this further, we developed a tetracycline-inducible mouse model of AML, in which the initial transforming event,...

    R Quéré, S Andradottir, A C M Brun, R A Zubarev, G Karlsson, K Olsson… in Leukemia (2011)

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  7. No Access

    Article

    Development of gene therapy for hematopoietic stem cells using lentiviral vectors

    Lentiviral vectors are promising tools for the development of gene therapy since they can transduce both quiescent and dividing target cells. Lentiviral vectors may be particularly promising gene delivery tool...

    N-B Woods, A Ooka, S Karlsson in Leukemia (2002)