-
Article
Are the effects of prolonged cold ischemia a barrier to long-distance transportation of living donor kidneys?
-
Article
Human Leukocyte Antigen Antibodies for Monitoring Transplant Patients
Human leukocyte antigen (HLA) antibody-mediated hyperacute rejection has dramatically decreased since the clinical introduction of crossmatch technology. However, the role of HLA antibody in acute and chronic ...
-
Chapter
Tissue Ty**, Crossmatching and the Allocation of Cadaveric Kidney Transplants
This chapter deals with the relevance of the major histocompatibility complex (MFC) to the results of clinical transplantations and its role in public policy decisions regarding the allocation of donor spares.
-
Article
Longmire Lecture: My 50 Years at the University of California, Los Angeles
The main concept driving my work has been the humoral theory of immunity to allografts. It led to the development of the microlymphocytotoxicity test, which is used to look for the relevant transplant antigen...
-
Article
Historic Landmarks in Clinical Transplantation: Conclusions from the Consensus Conference at the University of California, Los Angeles
The transplantation of organs, cells, and tissues has burgeoned during the last quarter century, with the development of multiple new specialty fields. However, the basic principles that made this possible we...
-
Chapter
Influence of rejection of the first transplant on the outcome of subsequent transplants
Patients who receive second cadaver transplants continued to pose unique challenges as they are considered to be immunized by their previous grafts. However, the success rates for renal retransplantation have ...
-
Chapter
Relative effect of HLA matching and cold ischemia time
One of the principal arguments against the use of HLA matching in renal transplantation is that, in most cases, cold ischemia time would be increased while a well-matched recipient is located and the kidney is...
-
Article
Cancer-associated quantitative differences in antigen levels of sialosyl Lewisx in stool from patients with colorectal carcinomas
A microenzyme-linked immunosorbent assay system employing monoclonal antibody SNH3 was developed for the detection of sialosyl Lewisx antigen in stool extracts from 80 patients with colorectal cancer, 13 patients...
-
Article
Cytotoxic T cell lines recognize autologous and allogeneic melanomas with shared or cross-reactive HLA-A
Cytotoxic T lymphocytes (CTL), CD3+, α/β T-cell-receptor-positive, are important effector cells with specific immunity in melanoma patients. The establishment and expansion in vitro of CTL of a specific phenotype...
-
Chapter
HLA matching and organ transplantation
Controversy still surrounds the issue of whether or not HLA matching should be used for recipient selection. There is lingering doubt that HLA ty** can select out such superior grafts from cadaver donors; ev...
-
Chapter
HLA-DP Region Complexity by CDC, RFLP, and Cellular Assays
HLA-DP, one of the class II complexes, had been originally typed only by the PLT method using cellular reagents (since 1980). Now, it can be defined by RFLP, but not by serologic methods. Strong secondary and ...
-
Chapter and Conference Paper
Analysis of Class II RFLP Patterns and T-Cell Clone Reactions
From the data distributed at the Princeton Workshop, we have been able to distinguish many alleles of the alpha and beta chains of the DR, DQ, and DP loci. In addition, alleles of the pseudogenes of the DO, DN...
-
Article
Immunohistochemical examination of lung cancers using monoclonal antibodies reacting with sialosylated Lewisx and sialosylated Lewisa
In order to explore the relationship between the expression of cancer-associated glycolipids such as sialylated Lex (SLEX) and sialylated Lea (SLEA) and the histological subtypes of lung cancers, 30 cases of smal...
-
Article
Antibody responses following rubella immunization analyzed by HLA and ABO types
HLA ty** was performed on 232 rubella seronegative (HAI antibody titer <8) children immunized with RA 27/3 vaccine. High convalescentphase geometric mean antibody titers were noted in children one to five ye...
-
Article
ANTIBODIES TO B-LYMPHOCYTES IN RENAL TRANSPLANTATION
Antibodies (ab) in the serum of allograft recipients against donor lymphocytes (L) are associated with graft rejection. Because ab may be produced against B cell (BC) antigens (ag) as well as HLA ag, we prospe...
-
Article
Cross-reactivity between human and murine lymphocyte antigens: III. Reactivity of H-2 allo- and xenoantisera with human lymphoid cells
H-2 alloantisera and antimouse lymphocyte xenoantisera react with 14%–100% of human lymphocytes from a panel of at least 80 unrelated people. Population and family studies did not reveal HL-A specificity of su...
-
Article
INCREASED INCIDENCE OF W27 IN JUVENILE RHEUMATOID ARTHRITIS
The frequencies of 24 hlstocompatibility antigens (HL-A) were examined in 26 patients with juvenile rheumatoid arthritis (JRA). Specificity W27 was noted in 42 per cent (11 patients) compared to 6 per cent of ...
-
Article
Leucocyte Antigens in Man : A Comparison of Lymphocytotoxic and Agglutination Assays for their Detection
-
Article
Microdroplet Assay of Human Serum Cytotoxins
ATTEMPTS to define leucocyte groups in man serologically have been hampered by the scarcity of immune human antisera and the capriciousness of the leuco-agglutination reaction1. The method recorded here for assay...
