HLA-DP Region Complexity by CDC, RFLP, and Cellular Assays

  • Chapter
Immunobiology of HLA

Abstract

HLA-DP, one of the class II complexes, had been originally typed only by the PLT method using cellular reagents (since 1980). Now, it can be defined by RFLP, but not by serologic methods. Strong secondary and weak primary proliferation responses were identified by Mawas (1), Wank (2), and Shaw (3), who classified them as SB antigens (SB1-5), and were officially designated by the 9th International Histocompatibility Workshop in 1984.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

eBook
USD 9.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Mawas C, Charmot D, Mercier P. Split of HLA-D into two regions alpha and beta by a recombination between HLA-d and GLO. 1.Study in a family and primed lymphocyte ty** for determinants coded by the beta region. Tissue Antigens 1980; 15: 458–466.

    Article  CAS  PubMed  Google Scholar 

  2. Wank R, Schendel D, Hansen JA, Dupont B. The lymphocyte restimulation system: Evaluation by intra-HLA-D group priming. Immunogenetics 1978; 6: 107–115.

    Article  Google Scholar 

  3. Shaw S, Johnson AH, Shearer GM. Evidence for a new segregant series of B cell antigens that are encoded in the HLA-D region and that stimulate secondary allogenic proliferative and cytotoxic responses. Exp Med 1980; 152: 565–580.

    Article  CAS  Google Scholar 

  4. Shaw S, Demars R, Schlossman S, Smith PL, Lampson LA, Nadler LM. Serologic identification of the human secondary b cell antigens. J Exp Med 1982; 156: 731–743.

    Article  CAS  PubMed  Google Scholar 

  5. Bodmer J, Bodmer W, Heyes J, So A, Tonics S, Trowsdale J, Young J. Identification of HLA-DP polymorphism with DPa and DPb probes and monoclonal antibodies: Correlation with primed lymphocyte ty**. Proc Natl Acad Sci USA 1987; 84: 4596–4600.

    Article  CAS  Google Scholar 

  6. Lotteau V, Teyton L, Tongio MM, Soulier A, Thomsen M, Sasportes M, Charron D. Biochemical polymorphism of the HLA-DP heavy chain. Immunogenetics 1987; 25: 403–407.

    Article  CAS  PubMed  Google Scholar 

  7. Seall SS, Lawrence J, Bradley D, Mattson DH, Singer D, Biddson W. B-chain gene rearrangements and Vb gene usage in DPw2-specific T cells. J Immunol 1987; 139: 1320–1325.

    Google Scholar 

  8. Odum N, Hofmann B, Hyldig-Nielsen JJ, Jakobsen BK, Morling N, Platz P, et al. A “new” supertypic HLA-DP related determinant detected by PLT. Tissue Antigens 1987; 29: 101–109.

    Article  CAS  PubMed  Google Scholar 

  9. Hyldig-Nielsen JJ, Morling N, Odum N, Ryder LP, Plata P, Jakobsen B, et al. Restriction fragment length polymorphism of the HLA-DP subregion and correlations to HLA-DP phenotypes. Proc Natl Acad Sci USA 1987; 84: 1644–1648.

    Article  CAS  PubMed  Google Scholar 

  10. Gorshi J, Rollini P, Mach B. Structural comparison of the genes of two HLA-DR supertypic groups: The loci encoding DRW52 and DRW53 are not truly allelic. Immunogenetics 1987; 25: 397–402.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer Science+Business Media New York

About this chapter

Cite this chapter

Park, M.S., Takenouchi, T., Terasaki, P.I., Tonai, R., Barbetti, A. (1989). HLA-DP Region Complexity by CDC, RFLP, and Cellular Assays. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_116

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-39946-0_116

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-38980-5

  • Online ISBN: 978-3-662-39946-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Navigation