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  1. No Access

    Article

    “It can't be done”

    Roy Y Calne in Nature Medicine (2012)

  2. No Access

    Article

    Stem cell and gene therapies for diabetes mellitus

    The ability of human embryonic stem cells to differentiate into pancreatic islet cells has defined the developmental stages and transcription factors involved in this process. As a consequence, refinement of g...

    Roy Y. Calne, Shu Uin Gan, Kok Onn Lee in Nature Reviews Endocrinology (2010)

  3. No Access

    Article

    Prope Tolerance: A Step in the Search for Tolerance in the Clinic

    Following the demonstration by Knechtle and colleagues that profound T cell depletion in rhesus monkeys treated with a CD3 diphtheria immunotoxin resulted in tolerance to renal allografting, we have used a si...

    Roy Y. Calne in World Journal of Surgery (2000)

  4. No Access

    Article

    Historic Landmarks in Clinical Transplantation: Conclusions from the Consensus Conference at the University of California, Los Angeles

    The transplantation of organs, cells, and tissues has burgeoned during the last quarter century, with the development of multiple new specialty fields. However, the basic principles that made this possible we...

    Carl G. Groth, Leslie B. Brent, Roy Y. Calne, Jean B. Dausset… in World Journal of Surgery (2000)

  5. No Access

    Article

    Tacrolimus-based immunosuppression after liver transplantation: a randomised study comparing dual versus triple low-dose oral regimens

    To evaluate the efficacy and safety of oral tacrolimus-based immunosuppressive induction therapy, 130 primary orthotopic liver transplant (OLT) recipients were randomised to treatment in an open, parallel-gro...

    P. Neuhaus, Jan M. Langrehr, Roger Williams, Roy Y. Calne… in Transplant International (1997)

  6. No Access

    Article

    The essential roles of parenchymal tissues and passenger leukocytes in the tolerance induced by liver grafting in rats

    Liver allografts in pigs and rodents are uniquely capable of inducing tolerance to themselves and to other grafts of donor tissues, instead of succumbing to the acute rejection that follows transplantation of ...

    Voravit Sriwatanawongsa, Hugh ff. S. Davies, Roy Y. Calne in Nature Medicine (1995)

  7. No Access

    Article

    Literature Abstract

    Richard W. E. Watts, Stephen H. Morgan, Christopher J. Dandpure… in Pediatric Nephrology (1992)

  8. No Access

    Article

    Graft-versus-host disease in solid organ transplantation

    Graft-versus-host disease is well recognized in bone marrow transplantation, but has only recently been described in solid organ transplantation. Two such cases in liver graft recipients, proven by the demonst...

    Neville V. Jamieson, Valerie Joysey, Peter J. Friend… in Transplant International (1991)

  9. No Access

    Chapter

    Clinical Posttransplant Followup

    The objective of pancreas transplantation is to normalize the carbohydrate metabolism. This in turn may have some influence on the development of secondary complications: it may stabilize or even reverse some ...

    I. G. M. Brons, Roy Y. Calne in Pancreas Transplantation (1988)

  10. No Access

    Article

    Organ transplantation with special emphasis on Cyclosporin A

    The history of organ transplantation and the development of immunosuppression therapy were discussed in detail, starting from Medawar's acquired immunological tolerence theory. The current status of transplant...

    Roy Y. Calne in The Japanese journal of surgery (1984)

  11. No Access

    Chapter

    Perspectives of Liver Transplantation in Cambridge

    The experimental technique of orthotopic liver transplantation was established by Starzl and Moore in 1959–1960 (Moore et al. 1959; Starzl et al. 1959).

    Keith Rolles, Roy Y. Calne in Artificial Liver Support (1981)