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Article
Open AccessDe novo lupus-like glomerulonephritis after pediatric non-kidney organ transplantation
We propose a novel clinically significant finding, de novo lupus-like glomerulonephritis (DNLLGN), in patients with autoantibodies and kidney abnormalities in pediatric liver transplant (LT) and intestinal inc...
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Article
Sirolimus and tacrolimus coefficient of variation is associated with rejection, donor-specific antibodies, and nonadherence
Immunosuppression medication nonadherence has been associated with donor-specific antibodies and treatment-refractory rejection. Drug-level monitoring is a practical direct marker for nonadherence, as variatio...
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Article
Bortezomib may stabilize pediatric renal transplant recipients with antibody-mediated rejection
Current therapeutic strategies to effectively treat antibody-mediated rejection (AMR) are insufficient. Thus, we aimed to determine the benefit of a therapeutic protocol using bortezomib for refractory C4d + A...
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Article
Accelerated rejection, thrombosis, and graft failure with angiotensin II type 1 receptor antibodies
Angiotensin II type 1 receptor antibodies (AT1R-Abs) have been implicated in renal transplant rejection and failure; however, the mechanism of allograft damage, patterns of clinical presentation, and response to ...
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Article
Optimizing HLA matching in a highly sensitized pediatric patient using ABO-incompatible and paired exchange kidney transplantation
Kidney transplantation is the treatment of choice for end-stage renal disease. However, since pediatric patients have long projected life-years, it is also optimal for them to get well-matched transplants to m...
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Article
Open AccessTrabecular bone volume and osteoprotegerin expression in uremic rats given high calcium
Calcium (Ca)-containing phosphate binders have been recommended for the treatment of hyperphosphatemia in children with chronic kidney disease. To study the effects of high Ca levels on trabecular bone volume ...
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Article
Growth hormone and the skeleton in pediatric renal allograft recipients
Recombinant human growth hormone has been utilized to augment linear growth in pediatric renal allograft recipients. The skeletal changes that accompany growth hormone therapy have not been described in childr...
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Article
Immediate post-transplant nephrosis in a patient with congenital nephrotic syndrome
A 19-month-old girl with congenital nephrotic syndrome of the Finnish type underwent a living-related renal transplant; 24 h after transplantation she became massively nephrotic. She did not respond to steroid...
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Article
Subcutaneous recombinant human erythropoietin in chronic renal allograft dysfunction
We investigated the efficacy and safety of subcutaneous recombinant human erythropoietin (rHuEpo) in 25 children with chronic renal allograft dysfunction (13 girls, 12 boys, mean age 15.8±4.2 years) for a tre...
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Article
Oral metronidazole does not improve cyclosporine A-induced gingival hyperplasia
Recently, resolution of cyclosporine A (CSA)-induced gingival hyperplasia was reported with antibiotic treatment. We therefore assessed the oral status of 45 children on CSA after renal transplantation and ev...
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Article
SUCCESSFUL BONE MARROW TRANSPLANT (BMT) IN SEVERE COMBINED IMMUNODEFICIENCY(SCID) FROM A SIBLING WHO HAD RECEIVED A PATERNAL HAPLOIDENTICAL BMT FOR SCID.• 71
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Article
Improved cadaveric renal transplant outcome in children
We analyzed the results of 165 pediatric cadaver renal transplants performed at the University of California at Los Angeles to identify the factors which are linked to improved allograft survival. Both univari...
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Article
Recombinant human growth hormone treatment of children following renal transplantation
Nine growth-retarded renal allograft recipients received either thrice weekly or daily subcutaneous recombinant human growth hormone (rhGH) for 6–30 months. The annualized growth velocity for the initial year ...
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Chapter
Renal Transplantation
Despite significant advances in dialysis technology, renal transplantation is the usual goal of therapy for children with end-stage renal disease (ESRD). A well-functioning kidney transplant improves a child’s...
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Article
Azathioprine suppression of natural killer activity and antibody-dependent cellular cytotoxicity in renal transplant recipients
The relative effects of azathioprine (AZA) and prednisone (PRED) on natural killer (NK) activity and the antibody-dependent cellular cytotoxicity (ADCC) of K (killer) cells and the number of FcR and other lymp...
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Article
THE USE OF FINE NEEDLE ASPIRATION BIOPSY (FNAB) FOR MONITORING IMMUNOLOGIC PHENOMENA POST-RENAL TRANSPLANTATION IN CHILDREN
No previous reports have described the use of FNAB in children. 70 FNAB were performed in 11 renal transplant (Tx) recipients with a mean age of 14.6 yrs. during the initial 6 post Tx months. The number of ser...
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Article
ANTIBODY MEDIATED RENAL TUBULAR DYSFUNCTION IN SJORGRENS SYNDROME (SS): EVIDENCE FOR TRANSPLANCENTAL TRANSFER OF IgG ANTIBODIES REACTIVE WITH RENAL TUBULAR CELL (RTC) ANTIGENS
Renal tubular dysfunction (type I- renal tubular acidosis (RTA) renal failure concentrating defects and Fanconi Syndrome) has been described with SS, but the mechanism(s) responsible are unclear. We describe a...
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Article
1109 HYPOPHOSPHATEMIA (HP) IN PEDIATRIC RENAL ALLOGRAFT RECIPIENTS(RAR)
HP following successful renal transplantation has been attributed to either antacid therapy or persistent hyperparathyroidism. The data of 115 RAR were reviewed to assess the relationship between serum phospha...
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Article
ANTIGEN IN CHILDREN UNDERGOING DIALYSIS AND TRANS-PLANTATION: A SERIAL STUDY
Between June 1970 and July 1976, all patients entering the Dialysis and Transplantation Program were tested serially for hepatitis B surface antigen (HBsag). 36 patients became HBsag positive (+). e antigen (e) t...
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Article
T CELL LEVELS IN PATIENTS ON DIALYSIS AND IN THE FIRST MONTH POSTTRANSPLANT
T cell levels are reported to be decreased in patients on dialysis and in the posttransplant (Tx) period. We have used the sheep erythrocyte rosette forming test (RFC) to measure the total number (TRFC) and pe...
