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  1. No Access

    Chapter and Conference Paper

    Time Course of Various Interstitial Metabolites Following Subarachnoid Hemorrhage Studied by on-Line Microdialysis

    Subarachnoid hemorrhage (SAH) is one of the most devastating of all cerebrovascular disorders [10]. One of the most serious complications of SAH remains vasospasm [3, 9]. Bedside cerebral microdialysis is a recen...

    A. S. Sarrafzadeh, O. W. Sakowitz, W. R. Lanksch, A. W. Unterberg in Cerebral Vasospasm (2001)

  2. No Access

    Chapter and Conference Paper

    Detection of Secondary Insults by Brain Tissue pO2 and Bedside Microdialysis in Severe Head Injury

    We evaluated bedside cerebral on-line microdialysis for early detection of cerebral hypoxia in patients with traumatic brain injury. 24 severely head injured patients (Glasgow Coma Score ≤ 8) were studied. Pat...

    Asita S. Sarrafzadeh, O. W. Sakowitz… in Intracranial Pressure and Brain Biochemica… (2002)

  3. No Access

    Chapter and Conference Paper

    Norepinephrine is Superior to Dopamine in Increasing Cortical Perfusion Following Controlled Cortical Impact Injury in Rats

    Following traumatic brain injury catecholamines are routinely applied to increase cerebral perfusion. To date, it remains controversial if infusion of catecholamines is associated with diminished cerebral perf...

    S.-N. Kroppenstedt, O. W. Sakowitz… in Intracranial Pressure and Brain Biochemica… (2002)

  4. No Access

    Chapter and Conference Paper

    Neuronal Activity Determined by Quantitative EEG and Cortical Microdialysis is Increased Following Controlled Cortical Impact Injury in Rats

    Following brain injury increased glutamate release is linked to sustained neuronal activation resulting in excitotoxic tissue damage. Isoflurane anesthesia has been shown to decrease electroencephalo-graphic (...

    O. W. Sakowitz, A. W. Unterberg… in Intracranial Pressure and Brain Biochemica… (2002)

  5. No Access

    Chapter and Conference Paper

    Neuronal activity and cortical perfusion determined by quantitative EEG analysis and laser Doppler flowmetry are uncoupled in brain injured rats

    Following traumatic brain injury uncoupling of metabolism from perfusion, reflected by an increase in cellular activity in face of reduced perfusion contributes to secondary tissue damage.

    J. F. Stover M.D, O. W. Sakowitz… in Mechanisms of Secondary Brain Damage from … (2004)

  6. No Access

    Chapter

    Erhöhter intrakranieller Druck

    Der Inhalt des Neurokrniums besteht uas weichen Hirngewebe, den bindegewebigen Hirnhäuten und -gefäßen (kompressibles Kompartiment) sowie den Flüssigkeiten Liquor und Blut (inkompressibles Kompartiment). Bei...

    A. W. Unterberg, O. W. Sakowitz in Die Intensivmedizin (2004)

  7. No Access

    Article

    Differential effects of prolonged isoflurane anesthesia on plasma, extracellular, and CSF glutamate, neuronal activity, 125I-Mk801 NMDA receptor binding, and brain edema in traumatic brain-injured rats

    Background. Volatile anesthetics reduce neuronal excitation and cerebral metabolism but can also increase intracellular water accumulation in normal and injured brains. While attenuation of neuronal excitation an...

    J. F. Stover, O. W. Sakowitz, S. N. Kroppenstedt, U. W. Thomale… in Acta Neurochirurgica (2004)

  8. No Access

    Chapter and Conference Paper

    Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact

    Granulocyte colony-stimulating factor (G-CSF) is an established treatment in the neutropenic host. Usage in headinjured patients at risk for infection may aggravate brain damage. In contrast, evidence of G-CSF...

    O. W. Sakowitz, C. Schardt, M. Neher, J. F. Stover, A. W. Unterberg… in Brain Edema XIII (2006)

  9. No Access

    Article

    An unusual case of a highly progressive supratentorial capillary haemangioblastoma – histopathological considerations

    We describe a case of a rapidly progressive, sporadic, non-von Hippel-Lindau (VHL) disease associated supratentorial capillary haemangioblastoma. Despite the classical histopathological presentation consisting...

    B. Orakcioglu, O. W. Sakowitz, A. Perren, F. L. Heppner… in Acta Neurochirurgica (2007)

  10. No Access

    Chapter and Conference Paper

    Serial diffusion and perfusion MRI analysis of the perihemorrhagic zone in a rat ICH model

    Cerebral ischemia has been proposed as a contributing mechanism to secondary neuronal injury after intracranial hemorrhage (ICH). We aimed to examine perihemorrhagic changes with an animal experimental MRI stu...

    Berk Orakcioglu M.D., K. Becker… in Changing Aspects in Stroke Surgery: Aneury… (2008)

  11. No Access

    Chapter

    Erhöhter intrakranieller Druck

    Der Inhalt des Neurokraniums besteht aus dem weichen Hirngewebe, den bindegewebigen Hirnhäuten und -gefäßen (kompressibles Kompartiment) sowie den Flüssigkeiten Liquor und Blut (inkompressibles Kompartiment). ...

    O.W. Sakowitz, A.W. Unterberg in Die Intensivmedizin (2008)

  12. No Access

    Chapter and Conference Paper

    Cerebral Microdialysis in Acutely Brain-Injured Patients with Spreading Depolarizations

    Multimodal cerebral monitoring was utilized to examine the relationship between pathological changes in microdialysis parameters and the occurrence of spreading depolarizations (SD) in brain-injured patients. ...

    K. L. Krajewski, B. Orakcioglu, D. Haux… in Early Brain Injury or Cerebral Vasospasm (2011)

  13. No Access

    Chapter

    Multiparametric Characterisation of the Perihemorrhagic Zone in a Porcine Model of Lobar ICH

    Objectives: To describe early perihemorrhagic changes after lobar intracerebral hemorrhage (ICH) using multiparametric neuromonitoring [intracranial pressure (ICP), cerebral blood flow (CBF), tis...

    Berk Orakcioglu, M. Kentar, Y. Uozumi, E. Santos… in Intracerebral Hemorrhage Research (2011)

  14. Article

    Standards of Scoring, Monitoring, and Parameter Targeting in German Neurocritical Care Units: A National Survey

    Optimal management of physiological parameters in neurological/neurosurgical intensive care units (NICUs) is largely unclear as high-quality evidence is lacking. The aim of this survey was to investigate if st...

    C. M. Kowoll, C. Dohmen, J. Kahmann, R. Dziewas, I. Schirotzek… in Neurocritical Care (2014)

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  15. No Access

    Article

    Neuigkeiten und Perspektiven der Neurointensivmedizin

    Die Neurointensivmedizin ist ein sich ständig weiterentwickelnder Teilbereich der Neurofächer, dessen Anwendung nachweislich zu Verbesserungen des Überlebens und des klinischen Ergebnisses bei Patienten mit sc...

    PD Dr. J. Bösel, M. Möhlenbruch, O.W. Sakowitz in Der Nervenarzt (2014)