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Article
Constructing Health State Descriptions for Low-Risk Thyroid Cancer: Stakeholder Engagement and Formative Qualitative Research
This paper describes stakeholder involvement and formative qualitative research in the creation of health state descriptions (HSDs) or vignettes for low-risk thyroid cancer. The aim of this project was to enga...
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Article
Charting the future of competency-based surgical education: a systematic review of cumulative sum
There is broad interest in the education community to shift surgical training from volume-based to competency-based benchmarks. Cumulative sum (CUSUM) is a method for tracking performance and identifying train...
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Chapter
Augmented Intelligence: Enhancing Human Decision Making
Augmented intelligence has been integrated into the daily lives of many individuals and it has now become the norm. Smart objects allow easier access to the Internet to enable quick searches or instructions. A...
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Article
Consequences of the packing problem
We study several consequences of the packing problem, a conjecture from combinatorial optimization, using algebraic invariants of square-free monomial ideals. While the packing problem is currently unresolved,...
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Article
Comparative analysis of suturing technique in pediatric pyeloplasty on surgical outcomes
Pyeloplasty for ureteropelvic junction obstruction is the gold standard for surgical repair. There are currently no reports outlining optimal suturing technique. This paper compares the effect of suturing tech...
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Article
Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells assembles large complexes called inflammasomes, which activate inflammatory caspases to process cytokines (IL-1β) and gasdermin...
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Article
Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases. Here we report ...
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Article
Open AccessApproaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding
Development of a prophylactic vaccine against hepatitis C virus (HCV) has been hampered by the extraordinary viral diversity and the poor host immune response. Scaffolding, by grafting an epitope onto a hetero...
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Chapter
(+)-11,11′-Dideoxyverticillin A
The dimeric epipolythiodiketopiperazine alkaloids are a family of fungal metabolites renowned for their structural and functional complexity [1]. Isolated across eight genera of fungi, over 40 members of this ...
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Article
Identification of predictive factors for perioperative blood transfusion in colorectal resection patients
Blood transfusion is associated with higher postoperative complication. With the availability of autologous blood and erythropoietin, it would be advantageous to identify patients who are at higher risk for re...
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Article
Selective treatment of rectal cancer with single-stage coloanal or ultralow colorectal anastomosis does not adversely affect morbidity and mortality
The surgical treatment of low rectal cancer commonly includes low pelvic anastomoses with coloanal or ultralow colorectal anastomoses. Anastomotic leak rates in low pelvic anastomoses range from 4 to 26%. Many...
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Article
Calmodulin Target Database
The intracellular calcium sensor protein calmodulin (CaM) interacts with a large number of proteins to regulate their biological functions in response to calcium stimulus. This molecular recognition process is...
